Tissue* | 3 dpi | 4 dpi | 5 dpi | 6 dpi | 7 dpi | Predominant cell types | Associated lesion |
---|---|---|---|---|---|---|---|
Proventriculus | – | – | – | + | – | Epithelial cells of the proventricular glands, cells of the muscularis externa | Severe multifocal necrosis, mild lymphoplasmacytic infiltrate |
Gizzard | – | – | + | ++ | ++ | Epithelial cells of the ventricular glands, cells of the muscularis externa | Severe multifocal necrosis, mild lymphoplasmacytic infiltrate |
Cecal tonsil | – | – | + | +++ | + | Cells of the lamina propria | Mild lymphoplasmacytic infiltrate |
Rectum | – | – | – | + | + | Cells of the muscularis externa of the lamina propria | Vacuolation, degeneration, mild lymphoplasmacytic infiltrate |
Pancreas | + | – | ++ | ++ | + | Acinar cells, endothelial cells | Severe multifocal to coalescent lytic necrosis, lymphoplasmacytic infiltrate, edema |
Kidney | + | + | + | + | +++ | Collecting tubular epithelial cells, endothelial cells | Moderate to severe necrosis, mild lymphoplasmacytic infiltrate |
Adrenal gland | + | – | – | – | – | Corticotrophic and corticotropic cells | NSL |
Nasal turbinates | – | ++ | – | – | – | Respiratory epithelial cells | Lymphoplasmacytic infiltrate in lamina propria |
Heart | + | ++ | +++ | ++ | +++ | Myocardiocytes, endothelial cells | Severe multifocal necrosis, mild lymphoplasmacytic infiltrate |
Skeletal muscle | – | – | + | ++ | ++ | Myocytes, endothelial cells | Moderate multifocal necrosis, mild lymphoplasmacytic infiltrate |
Spleen | – | – | – | – | + | Endothelial cells, macrophages | NSL |
Brain | ++ | +++ | +++ | +++ | +++ | Neurons, Purkinje cells, ependymal cells, glial cells, endothelial cells | Malacia in cortex, necrosis of ependymal cells of ventricles and epithelial cells of choroid plexus, chromatolysis of Purkinje cells, lymphoplasmacytic infiltrate. |