Alignment of amino acid sequences of Gag and Protease (Pro) proteins of BLV isolates. In (A), alignment of Gag polyprotein sequences is shown. Matrix (p15-MA), capsid (p24-CA) and nucleocapsid (p12-NC) protein sequences are shown in green, light blue and magenta, respectively. Zinc finger domains are shown in bold and italics. NC residues in boldface indicate basic residues. Conserved residues among BLV, HTLV-1 and HTLV-2 are shown bold underlined. In (B) alignment of protease (Pro) sequences is shown. Residues proven or predicted to be involved in S2 binding subsites are shown in bold. Residues that appear in HIV-1 drug resistance at the equivalent position in HIV-1 protease  are shown in bold underlined. The rest is the same as Figure 1.