Infection
|
FXa generation (nM)
|
---|
None (vehicle)
|
0
|
RacL11D752
|
2.24 ± 0.18*
|
RacL11N752
|
1.71 ± 0.02
|
Ab4D752
|
1.85 ± 0.10
|
Ab4N752
|
1.78 ± 0.08
|
- Monocyte-enriched PBMC fractions were infected with wild type RacL11D752 and Ab4D752 strains and engineered mutant strains (RacL11N752, Ab4N752) at an MOI of 5. Procoagulant activity was measured at 4 h after infection or vehicle (PBS) treatment (n = 4).
- * p < 0.05 versus mutant strain. All EHV-1 infected cells had significantly higher mean procoagulant activity than vehicle-treated cells.