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Table 4 Effect of the D 752 polymorphism in the virus DNA polymerase on EHV-1-induced procoagulant activity

From: Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes

Infection

FXa generation (nM)

None (vehicle)

0

RacL11D752

2.24 ± 0.18*

RacL11N752

1.71 ± 0.02

Ab4D752

1.85 ± 0.10

Ab4N752

1.78 ± 0.08

  1. Monocyte-enriched PBMC fractions were infected with wild type RacL11D752 and Ab4D752 strains and engineered mutant strains (RacL11N752, Ab4N752) at an MOI of 5. Procoagulant activity was measured at 4 h after infection or vehicle (PBS) treatment (n = 4).
  2. * p < 0.05 versus mutant strain. All EHV-1 infected cells had significantly higher mean procoagulant activity than vehicle-treated cells.
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Veterinary Research

ISSN: 1297-9716