Figure 3
From: Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes
Inactivation of virus with UV light or aphidicolin treatment decreases EHV-1-induced monocyte procoagulant activity. A: UV light inactivation decreases procoagulant activity induced with the RacL11 strain of EHV-1, whereas it has no effect on procoagulant activity induced by EHV-4 (n = 3). * p < 0.05 versus vehicle negative control. ** p < 0.05 versus EHV-4-infected cells (active or inactivated). B: Aphidicolin (10 μM) decreases the procoagulant activity induced by the RacL11 strain of EHV-1, but has no effect on basal procoagulant activity or that induced by LPS (10 ng/mL) (n = 3). The degree of inhibition of procoagulant activity with UV light inactivation and aphidicolin are similar. Note, results depicted in Figure 3A and B are derived from different horses. * p < 0.05 versus untreated or drug-treated vehicle (PBS) control. ** p < 0.05 versus UV light-exposed or aphidicolin-treated virus.