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Table 1 Effect of an O. ostertagi on transcript levels of signaling network components involved in gastric cell homeostasis (mean fold difference compared to uninfected calves ± SEM)

From: Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection

 

Single infection

Trickle infection

 

Experimental

Experimental

Natural

Gene

6 dpi

9 dpi

24 dpi

60 dpi

60 dpe

HB-EGF

2.61 ± 1.3

4.47 ± 0.68*

7.12 ± 1.33*

6.45 ± 1.11**

5.13 ± 1.31*

AREG

3.57 ± 1.78*

4.01 ± 0.82*

11.40 ± 1.58*

7.79 ± 0.77**

8.86 ± 2.48*

FGF10

2 ± 0.2

2.34 ± 0.43

4.33 ± 0.45*

1.83 ± 0.13**

2.58 ± 0.46*

HES1

1.79 ± 0.24*

2.07 ± 0.34*

2.3 ± 0.3*

3.20 ± 0.36**

1.97 ± 0.2*

ADAM10

1.66 ± 0.83*

2.44 ± 0.6*

2.64 ± 0.68*

1.76 ± 0.19

2.14 ± 0.22*

ADAM17

1.96 ± 0.25*

2.16 ± 0.29*

3.5 ± 0.6*

2.41 ± 0.25**

2.66 ± 0.26*

Wnt5A

1.93 ± 0.17*

1.92 ± 0.31*

3.09 ± 0.22*

2.76 ± 0.30**

2.01 ± 0.31*

SHH

2.25 ± 0.68

2.26 ± 1.06

1.98 ± 0.49

2.93 ± 0.61**

1.81 ± 0.44

BMP4

1.31 ± 0.16

1.7 ± 0.36

1.63 ± 0.14

1.69 ± 0.15

1.26 ± 0.09

FGF20

2.27 ± 0.33

2.87 ± 1.78

1.95 ± 0.31

1.44 ± 0.26

2.94 ± 0.31*

GIF

1.7 ± 0.22

1.13 ± 0.05

0.85 ± 0.15

0.61 ± 0.01**

0.72 ± 0.15

  1. *p value ≤ 0.05 uninfected animals vs infected animals.
  2. **p value ≤ 0.01 uninfected animals vs infected animals.
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Veterinary Research

ISSN: 1297-9716