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Table 1 Effect of an O. ostertagi on transcript levels of signaling network components involved in gastric cell homeostasis (mean fold difference compared to uninfected calves ± SEM)

From: Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection

  Single infection Trickle infection
  Experimental Experimental Natural
Gene 6 dpi 9 dpi 24 dpi 60 dpi 60 dpe
HB-EGF 2.61 ± 1.3 4.47 ± 0.68* 7.12 ± 1.33* 6.45 ± 1.11** 5.13 ± 1.31*
AREG 3.57 ± 1.78* 4.01 ± 0.82* 11.40 ± 1.58* 7.79 ± 0.77** 8.86 ± 2.48*
FGF10 2 ± 0.2 2.34 ± 0.43 4.33 ± 0.45* 1.83 ± 0.13** 2.58 ± 0.46*
HES1 1.79 ± 0.24* 2.07 ± 0.34* 2.3 ± 0.3* 3.20 ± 0.36** 1.97 ± 0.2*
ADAM10 1.66 ± 0.83* 2.44 ± 0.6* 2.64 ± 0.68* 1.76 ± 0.19 2.14 ± 0.22*
ADAM17 1.96 ± 0.25* 2.16 ± 0.29* 3.5 ± 0.6* 2.41 ± 0.25** 2.66 ± 0.26*
Wnt5A 1.93 ± 0.17* 1.92 ± 0.31* 3.09 ± 0.22* 2.76 ± 0.30** 2.01 ± 0.31*
SHH 2.25 ± 0.68 2.26 ± 1.06 1.98 ± 0.49 2.93 ± 0.61** 1.81 ± 0.44
BMP4 1.31 ± 0.16 1.7 ± 0.36 1.63 ± 0.14 1.69 ± 0.15 1.26 ± 0.09
FGF20 2.27 ± 0.33 2.87 ± 1.78 1.95 ± 0.31 1.44 ± 0.26 2.94 ± 0.31*
GIF 1.7 ± 0.22 1.13 ± 0.05 0.85 ± 0.15 0.61 ± 0.01** 0.72 ± 0.15
  1. *p value ≤ 0.05 uninfected animals vs infected animals.
  2. **p value ≤ 0.01 uninfected animals vs infected animals.