Different evolutionary trends of swine H1N2 influenza viruses in Italy compared to European viruses

Table 2 Selection pressure and positively selected sites in the HA and NA genes from viruses from different datasets.

1 → HA domains: E- vestigial esterase, RBD – Receptor binding domain, F – membrane fusion subdomain in the HA2 subunit [38]. NA domains: PIR – phylogenetically important regions described by Fanning et al. [39], NA head domain and antibody binding positions were previously reported by Gulati et al. [40].
2 → Antigenic sites in HA: Ca, Sa, Sb described by Caton et al. [37] and for H1N1pdm by Xu et al. [41]. Antigenic sites in NA: described by Colman et al. [42] and Air et al. [43].
Numbering is based on defining the first amino acid of the open reading frame as amino acid n. 1.

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