Neospora caninum specific placental lesions following subcutaneous challenge of pregnant cattle at day 210 of gestation. a: 28 dpi. A focus of necrosis (arrowheads), mainly affecting foetal mesenchyme but involving also adjacent areas of maternal caruncular septa. HE. ×100. b: 28 dpi. Serum leakage and formation of fibrin (red) is showed between the foetal villus (right) and the maternal septa (left). MSB. ×200. c: 42 dpi. Focus of necrosis affecting both maternal and foetal tissue. There is a marked mononuclear cell inflammation in the periphery of the focus (arrowheads). HE. ×100. d: 42 dpi. Focus of mononuclear inflammation (arrowhead) at the tunica intima and media of an arteriole located at the maternal caruncular septa. HE. ×200. e: 56 dpi. Prominent thickening and hypercellularity of the maternal caruncular septa (arrowheads). Atrophy and loss of trophectoderm of foetal villi adjacent to the thickened area (white arrowheads). HE. ×40. f: 56 dpi. Proliferation of connective tissue (green) in a thickened area of the maternal caruncular septa. Gomori Trichrome. ×40.