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Table 3 Abnormal electrocardiographic features in DNA-immunized dogs with experimental T. cruzi infection

From: Plasmid DNA immunization with Trypanosoma cruzi genes induces cardiac and clinical protection against Chagas disease in the canine model

GROUP 3 MONTHS PI (t3 = ACUTE STAGE) SUGGESTED PATHOLOGICAL CONDITIONS [[23],[24]] DOGS/n (%) 6 MONTHS PI (t4 = CHRONIC STAGE) SUGGESTED PATHOLOGICAL CONDITIONS [[23],[24]] DOGS/n (%)
pBCSP Long P wave (0.06 s vs. 0.04 s a), absence of some T waves, and tachycardia Intraventricular conduction defects 1/6 (17%) MEAD to the left, tall R wave in CV6LL (3.0 mV vs. 2.5 mVa), R wave greater in lead I than leads III and aVF Left ventricle enlargement 1/6 (17%)
Long P-R interval (0.14 s vs. 0.12 s a) AV block 1/6 (17%)    
pBCSSP4 Elevated S-T segment in leads I, III, aVF and CV6LL (0.5 mV vs. 0.2 mV a) Myocardial infarction and/or pericarditis 1/6 (17%) Several absent P waves Second-degree AV block 1/6 (17%)
Wide QRS complex (0.06 s vs. 0.05 sa), inverted QRS complex in leads aVR, aVL, and CV5RL, and a small Q in lead I (0.05 mV) Left BBB 1/6 (17%)
pBK-CMV Reversal polarity of the T wave, R wave greater than 2.5 mV in lead II, III, aVF, and CV6LL, MEAD less than +40º Left ventricular enlargement 3/6 (50%) Reversal polarity of the T wave Most often abnormal if it is found on serial EKG 2/6 (33%)
+ T wave more than 25% larger than the R wave, QRS complex with S wave in leads I, II, III, aVF, CV6LL and CV6LU Right BBB 1/6 (17%)
MEAD to the left, R wave exceeded of 2.5 mV in lead CV6LL, R wave in lead I greater than in leads III and aVF Left ventricle enlargement 3/6 (50%)
SS (mock-immunized) MEAD to the left, R wave exceeded of 2.5 mV in lead CV6LL, R wave in lead I greater than in leads III and aVF Left ventricle enlargement 2/6 (33%) MEAD to the left, R wave exceeded of 2.5 mV in lead CV6LL, R wave in lead I greater than in leads III and aVF Left ventricle enlargement 3/6 (50%)
+ arrhythmia Intraventricular conduction defects 1/6 (17%) Rhythm irregular, QRS complex premature, bizarre, and of large amplitude, T wave directed opposite the QRS VPC 1/6 (17%)
  + prolonged Q-T interval Intraventricular conduction defects 1/6 (17%) Reversal in polarity of the T wave Most often abnormal if it is found on serial EKG 2/6 (33%)
  1. PI post-infection.
  2. a Reference values[23, 24].
  3. BBB bundle branch block.
  4. AV atrioventricular.
  5. MEAD mean electrical axis deviation.
  6. VPC ventricular premature complexes.