|Mycoplasma species||Host species||Disease(s)||Apoptosis modulation mechanism||Reference|
|M. hyorhinis||swine||Polyserositis, otitis media, arthritis, pneumonia||Induces apoptosis in human carcinoma cell line AZ-521 by activation of NOS2 and caspase 3.|||
|M. bovis||cattle||Chronic unresponsive pneumonia, systemic infection, mastitis, arthritis||Inhibits proliferation without apoptosis or effect on function of lymphocytes and peripheral blood mononuclear cells. Induces apoptosis of bovine lymphocytes.||[10, 11]|
|M. fermentans||humans, mice||Possible role in arthritis (found in patients)||Reduces TNF-induced apoptosis upstream of caspase 8 in a myelomonocitic cell line. Prevents apoptosis of 32D cells by inducing NFκB gene upregulation. Promotes immortalization of human peripheral blood mononuclear cells in culture. Promotes proliferation of synovial fibroblasts.||[12–15]|
|M. alligatoris||alligators||Acute lethal cardiopulmonary disease||Promotes CD95 expression and apoptosis of primary cardiac fibroblasts through modulation of CD44 receptor.|||
|M. hominis||humans||Possible role in arthritis (found in patients)||Induces cell death in HeLa cells (through ATP release) and in 32D cells.||[14, 17]|
|M. penetrans||humans||Possible role in arthritis (found in patients)||
Mediates NFκB activation in mouse macrophages and induces apoptosis.|
Prevents apoptosis of 32D cells by inducing NFκB.
|M. arginini||humans, rodents, camels, sheep, pigs||Pneumonia, chronic respiratory disease, otitis||
Inhibits apoptosis of cells expressing toll-like receptors 2/6 by inducing constitutive NFkB activation and p53 suppression.|
Suppression of tp53 gene induces carcinogenic and mutagenic effects on rodent fibroblasts.
|M. genitalium||humans||Urethritis, pelvic inflammatory disease, pneumonia, arthritis||Does not affect 32D cells. Induces apoptosis in human monocytes THP-1 by activating NFκB.||[14, 21]|
|M. pneumoniae||humans||Atypical pneumonia, possible role in arthritis||Supports continous growth of 32D cells.|||