| |
Congenital infection
|
Cerebral infectionh
|
|---|
|
Group
|
Litter sizea
|
Stillbirth
|
Neonatal mortality
|
Vertical transmission
|
|---|
| | |
Per pupsb
|
Per littersc
|
Per pupsd
|
Per litterse
|
Per pupsf
|
Per littersg
| |
|---|
|
5 × 10
5
/challenged
†
|
5.0 ± 2.2
|
4/45 (8.8%)
|
2/9 (22.2%)
|
1/41 (2.4%)
|
1/8 (12.5%)
|
1/44 (2.3%)
|
1/9 (11.1%)
|
0/16 (0%)
|
|
Non-immunised/challenged
|
5.2 ± 1.7
|
8/58 (13.8%)
|
5/11 (45.5%)
|
42/50 (84%)
|
11/11 (100%)
|
41/46 (89.1%)
|
11/11 (100%)
|
13/16 (81.25%)
|
|
Non-immunised/non-challenged
|
4.6 ± 1.4
|
0/37 (0%)
|
0/8 (0%)
|
0/37 (0%)
|
0/8 (0%)
|
0/37 (0%)
|
0/8 (0%)
|
0/17 (0%)
|
|
5 × 10
5
/challenged
‡
|
4.6 ± 2.0
|
5/41 (12.2%)
|
4/9 (44.4%)
|
6/36 (16.6%)
|
2/9 (22.2%)
|
5/34 (14.7%)
|
4/9 (44.4%)
|
2/19 (10.5%)
|
|
5 × 10
4
/challenged
|
5.3 ± 1.3
|
8/79 (10.1%)
|
5/15 (33.3%)
|
8/71 (11.3%)
|
6/15 (40%)
|
9/75 (12%)
|
6/15 (40%)
|
1/24 (4.16%)
|
|
5 × 10
3
/challenged
|
5.8 ± 1.4
|
28/93 (30.1%)
|
11/16 (68.8%)
|
17/65 (26.1%)
|
7/15 (46.6%)
|
26/86 (30.2%)
|
7/15 (47%)
|
0/24 (0%)
|
|
5 × 10
2
/challenged
|
4.1 ± 1.5
|
4/41 (9.7%)
|
3/10 (30%)
|
7/37 (18.9%)
|
6/10 (60%)
|
14/41 (34.1%)
|
5/10 (50%)
|
1/26 (3.8%)
|
|
5 × 10/challenged
|
4.4 ± 1.9
|
14/44 (31.8%)
|
5/10 (50%)
|
2/30 (6.6%)
|
2/9 (22.2%)
|
2/37 (5.4%)
|
2/9 (22.2%)
|
2/25 (8%)
|
|
Non-immunised/challenged
|
5.0 ± 1.7
|
25/70 (35.7%)
|
8/14 (57.1%)
|
38/45 (84.4%)
|
13/13 (100%)
|
37/51 (72.6%)
|
13/13 (100%)
|
17/24 (70.8%)
|
|
Non-immunised/non-challenged
|
5.3 ± 1.6
|
3/64 (4.7%)
|
3/12 (25%)
|
0/61 (0%)
|
0/12 (0%)
|
0/64 (0%)
|
0/12 (0%)
|
0/24 (0%)
|
- † Experiment no. 1. Mice were randomly allocated in groups of 21–22 mice in experiment no. 1.
- ‡Experiment no. 2. The number of mice per group in experiment no. 2 was expanded to 29–31 mice to improve the statistical power by increasing the number. of pregnant mice per group.
- a Average ± SD.
- b No. of stillborns/no. of total pups born in the group (percentage).
- c No. of litters with at least one stillborn/no. of litters in the group (percentage).
- d No. of pups dead from birth to 30 days PP/no. of pups born alive (percentage).
- e No. of litters with at least one pup dead from birth to 30 days PP/no. of litters in the group (percentage).
- f No. of nested PCR-positive pups/no. of analysed pups (percentage).
- g No. of litters with at least one nested PCR-positive pup/no. of analysed litters (percentage).
- h No. of nested PCR-positive adult mice/no. of analysed adult mice in the group at the chronic infection phase (percentage).
