Increased footpad swelling correlated with high parasite burden in control mice at 7 weeks pi. (A) Course of footpad lesion development in BALB/c mice infected with L. major. (B) Parasite burden in the popliteal-DLN and spleen were determined at 7 weeks pi by limiting dilution (see Materials and Methods). ND: parasites not detected. Asterisks indicate P < 0.05 with respect to both groups of control mice. Results are the mean and SD (bars) in groups of mice (n = 6) from two independent experiments.