Profiles of PrPdaccumulation in the brain of recipients of either AAS (A-C) or VVC (D-F) inoculum. Individual profiles that show high degree of similarity are identified by the same colour (red, type A; pink, type A’; green, type M; light blue, type M’; gold, type U; orange, type U’; black, type P; brown, type CH). Note the high degree of variability amongst recipients of codon 136 heterologous transmissions (C and F), which contrasts with the consistency of profiles amongst homologous and semi-homologous transmissions recipients for both AAS (A and B) and VVC (D and E) inocula. PrPd types (X-axis) are: ITNR: intraneuronal; ITGL: intraglial; GLAS: glia-associated extracellular; NRPL: extracellular in grey matter neuropil; OTHR: other types. For more detailed description see text. Y-axis indicates proportion of the different PrPd types.