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Table 1 Replication and persistence of smooth virulent Brucella in mutant and knockout mice strains

From: What have we learned from brucellosis in the mouse model?

Test mouse strain Phenotypic defect Reference mouse strain Brucella spleen CFU increase and persistence relative to mouse reference straina References
Early before 14 days Late after 15 days
CBA/H Inbred no specific defect BALB/c [39]
CBA/H Inbred no specific defect C57BL/10 [39]
CBA/NJ Inbred no specific defect BALB/c [40]
DBA2 Inbred no specific defect C57BL/6 [41, 42]
CD-1 Outbreed Swiss mice BALB/c [40]
BALB/c Inbred no specific defect C3H/HeN [40]
BALB/c Inbred no specific defect C57BL/6 [39]
BALB/c Inbred no specific defect C57BL/10 [39]
BALB/c Inbred no specific defect C.CB (Nramp1r) [43]
C57BL/10 Inbred no specific defect B10Br [39]
C57BL/6 (TLR9) CpG motifs recognition C57BL/6 [44, 45]
BALB/c (TLR9) CpG motifs recognition BALB/c [46]
BALB/c (TLR4) LPS detection BALB/c [46]
BALB/c (TLR4) LPS detection BALB/c [44]
C3H/HeJ (TLR4) LPS detection C3H/HePas [47]
C3H/HeJ (TLR4) LPS detection C3H/HeAu [48]
C3H/HeJ (TLR4) LPS detection C3H/Heb [41, 42]
C3H/HeJ (TLR4) LPS detection C3H/HeN [40, 49]
C3H/HeJ (TLR4) LPS detection BALB/c [40]
C57BL/6 (TLR4) LPS detection C57BL/6 [50]
C57BL/6 (TLR2) Lipoproteins detection and peptidoglycan detection C57BL/6 [47, 50]
BALB/c (TLR2) Lipoproteins detection and peptidoglycan detection BALB/c [46]
BALB/c (TLR2) Lipoproteins detection and peptidoglycan detection BALB/c [44]
C57BL/6 (TLR2/4) LPS and lipoproteins detection C57BL/6 [50]
BALB/c (TLR2/4) LPS and lipoproteins detection BALB/c [44]
C57BL/6 (NOD1) muramyl peptides
meso-diaminopimelic acid
C57BL/6 ND [51]
C57BL/6 (NOD2) muramyl dipeptides C57BL/6 ND [51]
C57BL/6 (Myd88) Low proinflammatory response C57BL/6 [44, 45, 50]
C57BL/6 (TRIF) Low proinflammatory response C57BL/6 [44]
C57BL/6 (TRIF) Low proinflammatory response 129 Sv/Ev ND [44]
C57BL/10 (IRAK-4) Low proinflammatory response C57BL/6 [52]
C57BL/6 (Rip2) NOD adaptor protein C57BL/6 ND [51]
C57BL/6 (gp91phox) Low respiratory burst in phagocytes C57BL/6 [53]
C57BL/6 (iNOS) Low respiratory burst in phagocyte C57BL/6 [44]
C57BL/6 (iNOS) Low respiratory burst in phagocytes C57BL/6 [53]
C57BL/6 (IL-12p40) Early differentiation of Th1 cells C57BL/6 [53]
DBA/2j xC57BL/6 (iNOS/IL-12p40) Early differentiation of Th1 cells and low respiratory burst DBA/2j xC57BL/6 [53]
DBA/2 J (ICSBP) Deficient in IL-12p40 and
low respiratory burst
C57BL/6 [53]
C57BL/6 xDBA/2 J (iNOS/ICSBP) Deficient in IL-12p40 and
low respiratory burst
C57BL/6 xDBA/2 J [53]
C57BL/6 (IRF-2) Deficient in NK cells and dysregulation of IL-12p40 C57BL/6 [53]
C57BL/6 (igh6) Affects B cells C57BL/6 ↔/↓ [54]
C57BL/6 (igh6) Affects B cells C57BL/6 [55]
BALB/c (jh) Affects B cells BALB/c [55]
C57BL/6 (rag-1) Affects B and T cells C57BL/6 [54]
C57BL/6 (Cd4) Affects CD4 T cells C57BL/6 [54]
C57BL/6 (Aβ) Affects CD4 T cells C57BL/6 [56]
C57BL/6 (Aβ) Affects CD4 T cells C57BL/6 [55]
C57BL/6 (Pfp) Affects Restriction of Tc mediated killing C57BL/6 [57]
C57BL/6 (β2m) Affects CD8 T cells C57BL/6 [56]
C57BL/6 (β2m) Affects CD8 T cells C57BL/6 [54]
C57BL/6 (β2m) Affects CD8 T cells C57BL/6 [57]
C57BL/6 (β2m) Affects CD8 T cells C57BL/6 [55]
C57BL/6 (IL12/β2m) Affects CD8 T cells and
early differentiation of Th1 cells
C57BL/6 [58]
C57BL/6 (nu/nu) Lack thymus derived T cells C57BL/6 [59]
BALB/c (ifng) Absence of IFN-γ BALB/c ↑ Dead [57]
C57BL/6 (ifng) Absence of IFN-γ production C57BL/6 [44, 54, 58]
C57BL/6 (ifng) Absence of IFN-γ production C57BL/6 ↑ Dead [57]
C57BL/6 (ifng) Absence of IFN-γ production C57BL/6 [55]
C57BL/6 (ifng) Absence of IFN-γ production C57BL/6 ND [60]
C57BL/6 (IRF-1) CD8 T and NK cells dysregulation of IL-12p40 low respiratory burst C57BL/6 ↑ Dead [53]
BALB/c (infar1) More susceptible to viral Infections. Affects NK BALB/c [61]
C57BL/6 (INFαβR) More susceptible to viral Infections. Affects NK 129 Sv/Ev ND [62]
C57BL/6 (TCRδ) Absence of Tγδ cells C57BL/6 [60]
C57BL/6 (GM-CSF) Higher lung infection Defective alveolar macrophages C57BL/6 [60]
C57BL/6 (IL-17Rα) Defective in PMN recruitment and PMN activity C57BL/6 ND [60]
C57BL/6 (IL-1β) Low proinflammatory response C57BL/6 [50]
C57BL/6 (IL-18) Early activation of NK and Th1 cells C57BL/6 [50]
C57BL/6 (IL-1βx IL-18) Low proinflammatory response and recruitment of NK and Th1 cells C57BL/6 [50]
C57BL/10 (TNF-α) Low proinflammatory response C57BL/10 ND [63]
  1. Brucella susceptibility order: CBA/H>CBA/NJ=CD-1=BALB/c=C3H/HeN=C3H/HeJ>C57BL/10=C57BL/6≥B10Br.
  2. a (↑) Significantly higher numbers of CFU in spleen than in controls; (↓) significantly lower numbers of CFU in spleen than in controls; (↔) no significant number of CFU in spleen in relation to the controls; ND, not done.