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Table 1 Replication and persistence of smooth virulent Brucella in mutant and knockout mice strains

From: What have we learned from brucellosis in the mouse model?

Test mouse strain

Phenotypic defect

Reference mouse strain

Brucella spleen CFU increase and persistence relative to mouse reference straina

References

Early before 14 days

Late after 15 days

CBA/H

Inbred no specific defect

BALB/c

[39]

CBA/H

Inbred no specific defect

C57BL/10

[39]

CBA/NJ

Inbred no specific defect

BALB/c

[40]

DBA2

Inbred no specific defect

C57BL/6

[41, 42]

CD-1

Outbreed Swiss mice

BALB/c

[40]

BALB/c

Inbred no specific defect

C3H/HeN

[40]

BALB/c

Inbred no specific defect

C57BL/6

[39]

BALB/c

Inbred no specific defect

C57BL/10

[39]

BALB/c

Inbred no specific defect

C.CB (Nramp1r)

[43]

C57BL/10

Inbred no specific defect

B10Br

[39]

C57BL/6 (TLR9)

CpG motifs recognition

C57BL/6

[44, 45]

BALB/c (TLR9)

CpG motifs recognition

BALB/c

[46]

BALB/c (TLR4)

LPS detection

BALB/c

[46]

BALB/c (TLR4)

LPS detection

BALB/c

[44]

C3H/HeJ (TLR4)

LPS detection

C3H/HePas

[47]

C3H/HeJ (TLR4)

LPS detection

C3H/HeAu

[48]

C3H/HeJ (TLR4)

LPS detection

C3H/Heb

[41, 42]

C3H/HeJ (TLR4)

LPS detection

C3H/HeN

[40, 49]

C3H/HeJ (TLR4)

LPS detection

BALB/c

[40]

C57BL/6 (TLR4)

LPS detection

C57BL/6

[50]

C57BL/6 (TLR2)

Lipoproteins detection and peptidoglycan detection

C57BL/6

[47, 50]

BALB/c (TLR2)

Lipoproteins detection and peptidoglycan detection

BALB/c

[46]

BALB/c (TLR2)

Lipoproteins detection and peptidoglycan detection

BALB/c

[44]

C57BL/6 (TLR2/4)

LPS and lipoproteins detection

C57BL/6

[50]

BALB/c (TLR2/4)

LPS and lipoproteins detection

BALB/c

[44]

C57BL/6 (NOD1)

muramyl peptides

meso-diaminopimelic acid

C57BL/6

ND

[51]

C57BL/6 (NOD2)

muramyl dipeptides

C57BL/6

ND

[51]

C57BL/6 (Myd88)

Low proinflammatory response

C57BL/6

[44, 45, 50]

C57BL/6 (TRIF)

Low proinflammatory response

C57BL/6

[44]

C57BL/6 (TRIF)

Low proinflammatory response

129 Sv/Ev

ND

[44]

C57BL/10 (IRAK-4)

Low proinflammatory response

C57BL/6

[52]

C57BL/6 (Rip2)

NOD adaptor protein

C57BL/6

ND

[51]

C57BL/6 (gp91phox)

Low respiratory burst in phagocytes

C57BL/6

[53]

C57BL/6 (iNOS)

Low respiratory burst in phagocyte

C57BL/6

[44]

C57BL/6 (iNOS)

Low respiratory burst in phagocytes

C57BL/6

[53]

C57BL/6 (IL-12p40)

Early differentiation of Th1 cells

C57BL/6

[53]

DBA/2j xC57BL/6 (iNOS/IL-12p40)

Early differentiation of Th1 cells and low respiratory burst

DBA/2j xC57BL/6

[53]

DBA/2 J (ICSBP)

Deficient in IL-12p40 and

low respiratory burst

C57BL/6

[53]

C57BL/6 xDBA/2 J (iNOS/ICSBP)

Deficient in IL-12p40 and

low respiratory burst

C57BL/6 xDBA/2 J

[53]

C57BL/6 (IRF-2)

Deficient in NK cells and dysregulation of IL-12p40

C57BL/6

[53]

C57BL/6 (igh6)

Affects B cells

C57BL/6

↔/↓

[54]

C57BL/6 (igh6)

Affects B cells

C57BL/6

[55]

BALB/c (jh)

Affects B cells

BALB/c

[55]

C57BL/6 (rag-1)

Affects B and T cells

C57BL/6

[54]

C57BL/6 (Cd4)

Affects CD4 T cells

C57BL/6

[54]

C57BL/6 (Aβ)

Affects CD4 T cells

C57BL/6

[56]

C57BL/6 (Aβ)

Affects CD4 T cells

C57BL/6

[55]

C57BL/6 (Pfp)

Affects Restriction of Tc mediated killing

C57BL/6

[57]

C57BL/6 (β2m)

Affects CD8 T cells

C57BL/6

[56]

C57BL/6 (β2m)

Affects CD8 T cells

C57BL/6

[54]

C57BL/6 (β2m)

Affects CD8 T cells

C57BL/6

[57]

C57BL/6 (β2m)

Affects CD8 T cells

C57BL/6

[55]

C57BL/6 (IL12/β2m)

Affects CD8 T cells and

early differentiation of Th1 cells

C57BL/6

[58]

C57BL/6 (nu/nu)

Lack thymus derived T cells

C57BL/6

[59]

BALB/c (ifng)

Absence of IFN-γ

BALB/c

↑ Dead

[57]

C57BL/6 (ifng)

Absence of IFN-γ production

C57BL/6

[44, 54, 58]

C57BL/6 (ifng)

Absence of IFN-γ production

C57BL/6

↑ Dead

[57]

C57BL/6 (ifng)

Absence of IFN-γ production

C57BL/6

[55]

C57BL/6 (ifng)

Absence of IFN-γ production

C57BL/6

ND

[60]

C57BL/6 (IRF-1)

CD8 T and NK cells dysregulation of IL-12p40 low respiratory burst

C57BL/6

↑ Dead

[53]

BALB/c (infar1)

More susceptible to viral Infections. Affects NK

BALB/c

[61]

C57BL/6 (INFαβR)

More susceptible to viral Infections. Affects NK

129 Sv/Ev

ND

[62]

C57BL/6 (TCRδ)

Absence of Tγδ cells

C57BL/6

[60]

C57BL/6 (GM-CSF)

Higher lung infection Defective alveolar macrophages

C57BL/6

[60]

C57BL/6 (IL-17Rα)

Defective in PMN recruitment and PMN activity

C57BL/6

ND

[60]

C57BL/6 (IL-1β)

Low proinflammatory response

C57BL/6

[50]

C57BL/6 (IL-18)

Early activation of NK and Th1 cells

C57BL/6

[50]

C57BL/6 (IL-1βx IL-18)

Low proinflammatory response and recruitment of NK and Th1 cells

C57BL/6

[50]

C57BL/10 (TNF-α)

Low proinflammatory response

C57BL/10

ND

[63]

  1. Brucella susceptibility order: CBA/H>CBA/NJ=CD-1=BALB/c=C3H/HeN=C3H/HeJ>C57BL/10=C57BL/6≥B10Br.
  2. a (↑) Significantly higher numbers of CFU in spleen than in controls; (↓) significantly lower numbers of CFU in spleen than in controls; (↔) no significant number of CFU in spleen in relation to the controls; ND, not done.