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Figure 9 | Veterinary Research

Figure 9

From: What have we learned from brucellosis in the mouse model?

Figure 9

Spleen inflammation after infection of BALB/c mice with attenuated B. abortus S19 vaccine strain or virulent B. abortus 2308 (A) Generation of granulomas in the spleen (adapted from [[64]], with permission). (B) Histological sections stained with hematoxylin-eosine of spleens of CD-1 mice infected with B. abortus S19 after 6 weeks and with B. abortus 2308 after 8 weeks. As shown in Figure 2a, the spleen of S19 inoculated mice after 6 weeks of infection is considerably smaller than those infected with 2308. The proportion of the white pulp has been reestablished and the number of macrophages and neutrophils in the periphery of the central arteries of the nodules has considerably diminished in the spleens of S19 infected mice in relation to those infected with virulent 2308 strain, which is hyperemic and infiltrated with inflammatory cells.

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