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Table 2 Effect of stress on gene expression following BHV-1 infection

From: Stress significantly increases mortality following a secondary bacterial respiratory infection

 

WMS1

PA1

Gene

Day 0 2

Day 4 3

Day 0

Day 4

2'5'OAS

3.3 ± 2.84

0.9 ± 1.2*

2.7 ± 2.1

0.0 ± 1.5**

IL-β

6.8 ± 0.9

6.7 ± 0.8

7.0 ± 0.8

6.7 ± 0.6

TNF-α

6.1 ± 0.4

4.8 ± 0.7**

6.0 ± 0.4

4.9 ± 0.3**

IL-10

8.2 ± 0.8

5.7 ± 0.6**

8.1 ± 0.6

6.1 ± 0.3**

CD14

4.3 ± 0.7

3.4 ± 1.0*

4.2 ± 0.4

3.8 ± 0.7

TLR4

4.1 ± 0.9

3.2 ± 0.9*

4.0 ± 0.4

3.6 ± 0.6*

  1. 1Weaned and maternal separation (WMS) and pre-adapted (PA) calves (n = 10/group).
  2. 2PBMC isolated from calves prior to BHV-1 infection.
  3. 3PBMC isolated from calves 4 days post-BHV-1 infection and prior to M. haemolytica infection.
  4. 4Data presented are mean ΔCt ± 1SD with lower Ct value corresponding to greater transcript abundance.
  5. *p < 0.05 when Day 4 compared to Day 0 within each group; **P < 0.01 when Day 4 compared to Day 0 within each group.
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Veterinary Research

ISSN: 1297-9716