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Table 2 Antimicrobial activities and characteristics of equine antimicrobial peptides

From: Antimicrobial peptides and proteins of the horse - insights into a well-armed organism

Peptide family
Peptide
Mass [kDa] Charge
(at pH 7.5)
Specificity Salt
dependency
Citation
Cathelicidins      
eCATH-1
[GenBank: CAA12226]
3.1 8.8 Gram-positive/negative bacteria
Fungi
no
no
[35, 111]
eCATH-2
[GenBank: CAA12227]
3.6 2.8 Gram-positive/negative bacteria
Fungi
no
yes
[35, 111]
eCATH-3
[GenBank: CAA12228]
4.7 7.0 Gram-positive/negative bacteria
Fungi
yes
yes
[35, 111]
eCATH-4
[GenBank: XP_001495199.2]
n. d. n. d. n. d.   this review
EA-CATH-1
[GenBank: ACN93988.1]
3.1 6.8 Gram-positive/negative bacteria
Fungi
no
no
[43]
Defensins      
DEFB1
[GenBank: AAO32801]
4.0 5.2 n. d.   [36]
DEFL2
[GenBank: CAJ01792]
4.5 6.5 n. d.   [40, 145]
DEFL3
[GenBank: CAJ01793]
4.2 5.6 n. d.   [40, 145]
DEFB103
[GenBank: CAJ01801]
4.7 9.2 n.d.   [40, 145]
DEFA1
[GenBank: ABP96800]
4.1 6.3 Gram-positive/negative bacteria
Yeast
yes
yes
[4042, 131]
DEFA2 to 29
[GenBank: ACV49728-ACV49755]
3.6 - 5.5 2.3 - 9.2 n. d.   [41]
Neutrophil antimicrobial peptides      
eNAP-1
[GenBank: AAB22706]
7.2 n. d. Gram-positive/negative bacteria n. d. [33]
eNAP-2
[GenBank: AAB24353]
6.5 n. d. Gram-positive/negative bacteria n. d. [32, 34]
Lysozymes      
Equine lysozyme
[Swiss-Prot: P11376]
14.7 2.2 Gram-positive/negative bacteria n. d. [4648, 50]
NK-lysins      
Equine NK-lysin
[GenBank: AAN10122]
9.2 7.2 n. d.   [37, 82]
Psoriasin (S100A7)      
Psoriasin 1
[GenBank: CAH03717]
11.3 -6.2 Escherichia coli n.d. [39, 100]
Hepcidin      
Equine hepcidin
[GenBank: XM_001491610.2]
2.8 1.1 n. d.   [158]
  1. Peptide masses and charges that have not been determined experimentally were complemented using the ProteinCalculator v3.3 software [193].