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Figure 7 | Veterinary Research

Figure 7

From: Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues

Figure 7

Perforin production by CD8+ T cells isolated from lymphoid and non-lymphoid organs during WD-MCF in rabbits. At time of euthanasia, analysis by multi-colour flow cytometry was conducted on PBMC and mononuclear leukocytes isolated from pLN, spleen, liver, lung and kidney of mock-infected or AlHV-1-infected rabbits developing WD-MCF. (A) Flow cytometry dot plots obtained by multi-colour staining of PBMC and mononuclear leukocytes isolated from pLN, spleen, liver, lung and kidney of one representative rabbit of each group at time of euthanasia. (B) Perforin production in CD8+ cells at time of euthanasia in each lymphoid and non-lymphoid selected tissue. Data are representative of two independent experiments (n = 3). Bars show means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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Veterinary Research

ISSN: 1297-9716