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Figure 2 | Veterinary Research

Figure 2

From: Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues

Figure 2

Induction of WD-MCF in rabbits. On day 0, two groups, each consisting of three rabbits, were inoculated intravenously with 3 × 106 mock-infected or AlHV-1-infected BT cells. Rabbits developing WD-MCF were euthanized when rectal temperature remained higher than 40°C for two consecutive days. Rabbits were identified according to their infected (IR) or mock-infected (MR) status and according to the time of euthanasia (see numbers). (A) Survival curve of AlHV-1-infected rabbits. (B) Relative percentages of B cells (IgM+), monocytes (CD14+), T cells (T-lymphocytes+), CD4+ and CD8+ cells in PBMC isolated from both groups every 4-5 days after infection, stained and analyzed by flow cytometry as described in Figure 1. Data are representative of two independent experiments (n = 3).

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