Table 1 To date identified colonization factors of Campylobacter jejuni in the avian gastrointestinal tract
From: Colonization factors of Campylobacter jejuni in the chicken gut
Functional area | Gene name or locus | Identified/predicted protein function | Reference |
|---|---|---|---|
Multidrug efflux pump | cmeABC cmeR cj0561c cbrR* | Campylobacter multidrug efflux pump transcriptional repressor of cmeABC putative periplasmic protein Campylobacter bile resistance orphan response regulator | [24] [25] [27] |
Chemotaxis | docB docC acfB cheY tlp1 luxS cheB, cheR | probable methyl-accepting chemotaxis protein (MCP) probable MCP protein probable MCP protein chemotaxis regulatory protein chemoreceptor transducer-like protein signal autoinducer AI-2 biosynthesis enzyme putative adaptation proteins | [32] [26] [32] [33] [35] [29] |
Motility | flaA maf5 rpoN fliA flgR flgK cj1321 - cj1325/6 | major flagellin motility accessory factor (flagellar biosynthesis) RNA polymerase σ54 subunit RNA polymerase σ28 subunit response regulator possible flagellar hook associated protein flagellin O-linked glycosylation island | [44] [52] |
Capsule formation and N-linked glycosylation | kpsM pglH cj1496c | high molecular weight glycan probable glycosyltransferase glycoprotein with unknown function | [44] [66] |
Two-component regulatory systems | racR - racS dccR - dccS cbrR cprR - cprS flgR - flgS | reduced ability to colonize regulatory system diminished capacity to colonize regulatory system Campylobacter bile resistance orphan response regulator Campylobacter planktonic growth regulation regulatory system flagellar signal transduction system | [71] [72] [27] [73] |
Temperature regulation and heat shock response | dnaJ racR | heat-shock protein reduced ability to colonize response regulator | [71] |
Adhesion | capA? cadF pldA peb1A flpA | autotransporter lipoprotein outer membrane fibronectin-binding protein outer membrane phospholipase A periplasmic ABC transporter of amino acids fibronectin-like protein A | |
Invasion | ciaB docB docC tlp1 | Campylobacter invasion antigen B probable MCP protein probable MCP protein chemoreceptor transducer-like protein | [55] |
Iron regulation | feoB fur cfrA ceuE cfrB chuA cj0178 znuA | specific transporter protein ferric uptake regulator (recessive) ferric enterobactin (FeEnt) receptor FeEnt-uptake periplasmic binding protein (dominant) FeEnt receptor hemin uptake outer membrane protein putative transferrin-bound iron utilization outer membrane receptor periplasmic component of a putative zinc ABC transport system | [89] [88] [90] [26] [88] [91] |
Oxidative and nitrosative stress response | docA cj0358 sodB perR ahpC katA ggt ppk1 ppk2 tatC cj0379c | putative cytochrome c peroxidase putative cytochrome c peroxidase superoxide dismutase peroxide-sensing regulon alkyl-hydroxyperoxidase peroxide stress regulon catalase γ-glutamyl transpeptidase polyphosphate kinase 1 polyphosphate kinase 2 twin-arginine translocase (TAT) secretion system TAT translocated molybdo-enzyme | [26] [95] [99] [101] [102] [108] [107] |
Central intermediary and energy metabolism | frdABC operon aspA hydABCD operon fdhABCD operon oorDABC (12) nuo genes nrfA napAGHBLD operon ccoNOQP operon sdaA cj0415 livJ cj0903c peb1A ggt | fumarate reductase aspartate ammonia-lyase hydrogenase formate dehydrogenase 2-oxoglutarate:acceptor oxidoreductase NADH:ubiquinone oxidoreductase (complex I) nitrite reductase nitrate reductase cbb 3 -type cytochrome c oxidoreductase L-serine dehydratase putative oxidoreductase subunit putative amino acid ABC transporter periplasmic-binding protein putative amino acid transport protein periplasmic ABC transporter of amino acids γ-glutamyl transpeptidase | [109] [110] [111] [112] [32] |