PrPScaccumulation patterns in the brain of H-type BSE-challenged cattle. Fine particulate-type PrPSc accumulation in the neuropil of the frontal cortex (a). Coarse particulate-type (b), perineuronal-type (c), and linear-type (d) PrPSc deposition in the thalamus. Stellate-type deposition in the caudate nucleus (e, arrows). Plaque-like (f, arrow) and stellate-type (f, arrowhead) deposition in the cerebral cortex. Intraneuronal-type PrPSc accumulation in the olivary nucleus (g). Intraglial-type PrPSc deposition in the cerebellar medulla (h). The images show immunohistochemical labeling with mAb F99/97.6.1 and hematoxylin counterstaining. Scale bars = 20 μm.