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Table 4 The 20 most up-regulated transcripts detected in Expts. 1 and 2 (FDR ≤ 0.05)

From: Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta

Sequence.ID TIGR_TC TC. description Gene symbol Fold Change
EXPT 1. Comparison = Nvd5/Nvd0
KN511_9480n02.p1kaM13F TC385850 --- --- 5.44
C0009213B13 --- --- --- 1.81
KN511_9261j08.p1kaM13F --- --- --- 1.77
KN511_9255d18.p1kaM13F TC307335 laminin B1 LAMB1 1.64
KN511_9486f02.p1kM13F TC305120 UP|GRAA_BOVIN (Q7YRZ7) Granzyme A precursor, complete gzmA 1.59
KN511_9488i01.p1kM13F TC311345 homologue to UP|Q96IL1_HUMAN (Q96IL1) DIAPH1 protein (Fragment), partial (43%) LOC786565 1.55
KN511_9483h09.p1kM13F TC302202 UP|Q3T119_BOVIN (Q3T119) FCGRT protein, complete FCGRT 1.53
CN822687 TC381381 similar to emb|X79547.1|MIECCOMP Equus caballus mitochondrial DNA complete sequence, partial (4%) --- 1.52
KN511_9257n17.p1kaM13F --- --- --- 1.52
KN511_9479d15.p1kaM13F TC361081 similar to UP|O97916_BOVIN (O97916) Reverse transcriptase-like, partial (43%) --- 1.51
KN511_9486m17.p1kM13F TC303503 UP|C1QA_BOVIN (Q5E9E3) Complement C1q subcomponent subunit A precursor, complete C1QA 1.50
KN511_9257l13.p1kaM13F --- --- --- 1.50
KN511_9479o01.p1kaM13F TC355858 GB|AAI02065.1|74353831|BC102064 CCL5 protein {Bos taurus} (exp = -1; wgp = 0; cg = 0), complete CCL5 1.50
CN823601 TC342786 --- --- 1.50
KN511_9486d22.p1kM13F TC337098 UP|Q3SZV9_BOVIN (Q3SZV9) Heat shock 10kDa protein 1 (Chaperonin 10), complete HSPE1 1.50
KN511_9477j24.p1kaM13F TC301808 UP|Q3ZC91_BOVIN (Q3ZC91) Sphingomyelin phosphodiesterase, acid-like 3A, complete LOC781963 1.48
KN511_9485e22.p1kM13F --- --- --- 1.48
KN511_9253n18.p1kaM13F TC317864 UP|Q3KZ51_SCHJA (Q3KZ51) SJCHGC03568 protein (Fragment), partial (6%) MGC139367 1.48
KN511_9265g17.p1kaM13F TC319596 homologue to UP|TCEA3_HUMAN (O75764) Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h), complete MGC137536 1.48
KN511_9265b23.p1kaM13F --- --- --- 1.48
EXPT 1 Comparison = Imd5/Nvd5
KN511_9264h11.p1kaM13F TC331976 homologue to UP|Q864L7_BOVIN (Q864L7) Granulysin/NK-lysin-like protein (Fragment), complete GNLY 94.0
KN511_9257k12.p1kaM13F --- --- --- 5.91
KN511_9263m23.p1kaM13F TC306994 similar to UP|Q9TUB5_PIG (Q9TUB5) Epithelial chloride channel protein, partial (95%) CLCA1 5.15
KN511_9253n09.p1kaM13F TC328399 similar to UP|Q67BC3_HUMAN (Q67BC3) Endogenous granzyme B, partial (90%) LOC508646 5.14
KN511_9265g07.p1kaM13F TC351879 --- LOC614719 4.70
KN511_9260m05.p1kaM13F --- --- --- 4.64
KN511_9260b08.p1kaM13F TC330838 --- --- 4.27
CN823175 --- --- --- 3.14
CN823115 TC329726 homologue to GB|CAA44699.1|440|BTIGG1HCX anti-testosterone antibody {Bos taurus} (exp = -1; wgp = 0; cg = 0), partial (70%) IGHG1 2.72
KN511_9480o15.p1kaM13F --- --- --- 2.66
KN511_9476e05.p1kaM13F TC330547 similar to UP|NBR1_PONPY (Q5RC94) Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein), partial (23%) LOC515032 2.64
KN511_9486a03.p1kM13F TC350940 similar to UP|CAD26_MOUSE (P59862) Cadherin-like protein 26 precursor, partial (11%) LOC617096 2.47
CO202749 TC366134 similar to UP|Q48MR5_PSE14 (Q48MR5) Uncharacterized protein family UPF0016, partial (58%) --- 2.45
KN511_9486o13.p1kM13F TC322636 weakly similar to UP|Q9R0M7_MOUSE (Q9R0M7) Aldo-keto reductase AKR1C12, partial (91%) LOC507734 2.42
CN824147 --- --- --- 2.38
CN823337 TC313767 UP|Q2FLD4_METHJ (Q2FLD4) ABC transporter related, partial (6%) --- 2.37
CO203065 TC321552 --- --- 2.34
KN511_9487e05.p1kM13F TC302266 GB|AAC67307.1|1930063|BTU92535 neuronal axonal membrane protein {Bos taurus} (exp = -1; wgp = 0; cg = 0), complete BASP1 2.30
KN511_9261f23.p1kaM13F --- --- --- 2.29
KN511_9478a01.p1kaM13F TC347423 similar to UP|GRAH_HUMAN (P20718) Granzyme H precursor (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C), partial (93%) LOC617313 2.28
KN511_9486l10.p1kM13F TC315163 similar to GB|AAH12303.1|15126763|BC012303 PDZK1 interacting protein 1 {Homo sapiens} (exp = -1; wgp = 0; cg = 0), complete PDZK1IP1 2.21
CN824077 --- --- --- 2.21
CN824594 TC359921 homologue to UP|Q4K9Y4_PSEF5 (Q4K9Y4) BNR/Asp-box repeat protein, partial (41%) --- 2.14
KN511_9260m24.p1kaM13F --- --- --- 2.13
EXPT 2 Comparison = Imd0/Nvd0
KN511_9484k05.p1kM13F TC323139 similar to UP|Q4TA31_TETNG (Q4TA31) Chromosome undetermined SCAF7459, whole genome shotgun sequence, partial (10%) --- 3.59
KN511_9263m23.p1kaM13F TC306994 similar to UP|Q9TUB5_PIG (Q9TUB5) Epithelial chloride channel protein, partial (95%) CLCA1 2.99
KN511_9484p11.p1kM13F --- --- --- 2.08
KN511_9485e08.p1kM13F TC312631 --- --- 1.61
KN511_9478a06.p1kaM13F TC312631 --- --- 1.49
KN511_9481c23.p1kaM13F TC314684 --- --- 1.46
CN823114 TC301217 homologue to UP|NDRG1_HUMAN (Q92597) Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Differentiation-related gene 1 protein) (DRG-1) (Reducing agents and tunicamycin-responsive protein) (RTP) (Nickel-specific induction protein Cap43) (Rit42), partial (97%) NDRG1 1.37
KN511_9257n17.p1kaM13F --- --- --- 1.35
CN823685 TC315004 similar to UP|Q3TT48_MOUSE (Q3TT48) Adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330433L19 product:proprotein convertase subtilisin/kexin type 2, full insert sequence. (Fragment), partial (3%) LOC615685 1.33
KN511_9476g20.p1kaM13F TC337413 UP|CYTC_BOVIN (P01035) Cystatin C precursor (Colostrum thiol proteinase inhibitor), complete CST3 1.31
  --- --- --- 1.30
KN511_9259b18.p1kaM13F TC371167 --- --- 1.29
KN511_9479a08.p1kaM13F TC318244 UP|CATA_BOVIN (P00432) Catalase, partial (5%) MGC128112 1.29
CN823587 --- --- --- 1.27
CO202780 TC357183 UP|Q71V68_MOUSE (Q71V68) Ldb1a, complete LOC526472 1.26
KN511_9262a18.p1kaM13F TC308953 UP|Q3T013_BOVIN (Q3T013) BCL2/adenovirus E1B 19kDa interacting protein 3-like, partial (84%) BNIP3L 1.26
CO202648 TC301621 homologue to UP|Q9HB23_HUMAN (Q9HB23) Lysyl-tRNA synthetase, complete MGC127504 1.25
KN511_9254i12.p1kaM13F TC381609 homologue to UP|Q963G4_PLAFA (Q963G4) MB2 (Fragment), partial (3%) LOC508133 1.25
KN511_9261e18.p1kaM13F --- --- --- 1.24
EXPT 2 Comparison = Imd2/Imd0
KN511_9481e19.p1kaM13F TC318483 --- LRIG1 10.2
KN511_9256h20.p1kaM13F TC309152 similar to UP|O97916_BOVIN (O97916) Reverse transcriptase-like, partial (19%) --- 10.0
KN511_9257i19.p1kaM13F TC375873 --- --- 9.71
KN511_9481f19.p1kaM13F TC345827 homologue to GB|CAI11042.1|55859631|AL353665 match: proteins: Q92802 {Homo sapiens} (exp = 0; wgp = 1; cg = 0), partial (35%) LOC541201 9.17
KN511_9480f18.p1kaM13F --- --- --- 8.94
CN822322 TC309241 nucleolin [Bos taurus] NCL 8.03
KN511_9483a22.p1kM13F TC316336 UP|Q3ZCJ8_BOVIN (Q3ZCJ8) Cathepsin C, complete CTSC 7.52
KN511_9263m23.p1kaM13F TC306994 similar to UP|Q9TUB5_PIG (Q9TUB5) Epithelial chloride channel protein, partial (95%) CLCA1 7.33
KN511_9483l13.p1kM13F TC340529 homologue to UP|Q9BTX0_HUMAN (Q9BTX0) RNA binding motif protein 10, isoform 2, partial (69%) RBM10 6.73
KN511_9488g12.p1kM13F TC304325 similar to GB|CAJ18388.1|71059689|CT010180 {Mus musculus} (exp = -1; wgp = 0; cg = 0), complete MGC127625 6.46
KN511_9263i18.p1kaM13F TC332274 UP|Q7ZU59_BRARE (Q7ZU59) H2AV protein (Fragment), partial (87%) H2AFZ 6.45
KN511_9253j02.p1kaM13F TC331773 homologue to UP|HSP76_PIG (Q04967) Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B'), complete HSPA6 6.11
KN511_9487k02.p1kM13F TC385703 UP|VPS28_MOUSE (Q9D1C8) VPS28 protein homolog (Caspase-activated DNase inhibitor that interacts with ASK1) (CIIA), complete VPS28 5.97
KN511_9265g07.p1kaM13F TC351879 --- LOC614719 5.84
KN511_9476g04.p1kaM13F TC371801 homologue to SP|O60506|HNRPQ_HUMAN Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (hnRNP-Q)(Synaptotagmin binding, cytoplasmic RNA interacting protein) (Glycine-and tyrosine-rich RNA binding protein) (GRY-RBP) (NS1-associatedprotein 1). {Homo sapiens} (exp = -1; wgp = -1; cg = -1), partial (51%) SYNCRIP 5.58
KN511_9263f17.p1kaM13F TC355165 similar to UP|Q9XSA0_SHEEP (Q9XSA0) Pulmonary surfactant-associated protein B (Fragment), partial (16%) --- 4.64
KN511_9476p04.p1kaM13F TC329988 UP|Q5E973_BOVIN (Q5E973) Ribosomal protein L18, complete RPL18 4.47
KN511_9480l18.p1kaM13F TC364833 --- --- 4.38
KN511_9265h18.p1kaM13F TC303880 homologue to UP|O35328_MOUSE (O35328) Proline-rich protein 9-1 (Fragment), partial (6%) --- 4.18
KN511_9260b08.p1kaM13F TC330838 -- --- 4.15
  1. The experiment and the samples being compared are given as subheadings at the top of each section. Nv = "naïve" yearlings, worm naïve prior to challenge; Im = "immune" yearlings, previously infected by trickle infection prior to challenge, d = days post-challenge. Details of the experimental trials and hybridisation design are given in Tables 1 and 2.