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Table 1 Design of T. circumcincta infection trials in yearling sheep

From: Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta

Trial Group Treatment Days post-challengea; no. of sheep
   Trickle infn b clearance c 0 d 2 5 10 21
Expt. 1 Naïve (Nv) - + 6 - 6 6 6
  Immune (Im)e + + - - 6 6 -
Expt. 2 Naïve (Nv) - + 6 6 - - -
  Immune (Im)e + + 6 6 - - -
  1. The experimental model of infection used in this study is summarised. Details are given in the footnotes. Two experimental trials were carried out; Expt.1; addressing differences between immune ("previously infected") and naïve sheep at days 5 and 10 post challenge, and Expt.2, addressing differences between immune and naïve and sheep without challenge (day 0) and early post-challenge (day 2).
  2. a1 × 50 000 T. circumcincta L3 on Day 0
  3. b2000 T. circumcincta L3 3 × per wk for eight weeks
  4. cLevamisole (7.5 mg/kg) 7 days before challenge
  5. dDay 0 = unchallenged
  6. epreviously infected by trickle infection