The current status and future directions of myxoma virus, a master in immune evasion

Table 1 Comparison of symptoms in wild and domestic rabbits infected with different MYXV strains inducing nodular myxomatosis (adapted from [7, 11]).

Day pi	Laboratory rabbits			Wild rabbits
	SLS	Lausanne	Uriarra (Ur)	SLS	Uriarra (Ur)
1
2	Pink & edematous inoculation site	Pink/edematous inoculation site		Pink inoculation site
3			Pink/edematous inoculation site
4	Conjunctivitis	Conjunctivitis			Pink inoculation site
5		Secondary skin lesions Anogenital edema		Conjunctivitis Anogenital edema
6	Secondary skin lesions & anogenital edema	Serous eye discharge	Conjunctivitis & Anogenital edema
7	Respiratory distress	Mucopurulent eye discharge & purple/black inoculation site			Mild conjunctivitis
8		Necrotic inoculation site; Edematous eyelids; Respiratory distress		Secondary skin lesions
9			Secondary skin lesions
10	Severe respiratory distress Secondary lesions across the skin ^#	Serous secretion from inoculation site	Respiratory distress	Respiratory distress	Mild anogenital edema; Secondary skin lesions
11		Severe dyspnoea; Secondary lesions across the skin ^#
12				Lesion regression
13
Day pi	Laboratory rabbits			Wild rabbits
14
15				Improved breathing; Decreased anogenital edema	Lesion regression
16
17			Lesion regression
18
19
20			Still recovering	Virtually recovered

^#: euthanasia of the experimentally infected animals due to too severe clinical symptoms; pi: post inoculation

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