|
Gene
| | |
Infectionb
|
|---|
| |
6 dpi
|
9 dpi
|
24 dpi
|
60 dpe
|
|
Mucins
| | | | |
|
Membrane bound
| | | | |
|
MUC1
|
2.07 ± 0.3*
|
2.93 ± 0.3*
|
3.29 ± 0.3*
|
2.75 ± 0.2*
|
|
MUC20
|
2.78 ± 0.5*
|
1.50 ± 0.2*
|
3.99 ± 0.6*
|
3.28 ± 0.6*
|
|
Secreted gel forming
| | | | |
|
MUC2
|
n.dc
|
n.d
|
n.d
|
n.d
|
|
MUC5AC
|
4.08 ± 1.1*
|
2.25 ± 0.5*
|
1.50 ± 0.2*
|
1.56 ± 0.7*
|
|
MUC5B
|
n.d
|
n.d
|
n.d
|
n.d
|
|
MUC6
|
3.09 ± 1.0*
|
2.80 ± 0.4*
|
4.39 ± 1.4*
|
4.52 ± 0.5*
|
|
Trefoil Factors
| | | | |
|
TFF1
|
3.89 ± 1.5*
|
3.32 ± 0.8*
|
2.57 ± 0.2*
|
3.90 ± 0.5*
|
|
TFF2
|
2.50 ± 1.1*
|
4.12 ± 2.4*
|
2.22 ± 0.8*
|
3.81 ± 1.4*
|
|
TFF3
|
2.59 ± 0.8*
|
18.57 ± 11.7*
|
58.57 ± 13.2*
|
49.28 ± 16.7*
|
|
Glycosyltransferases
| | | | |
|
Core structure
| | | | |
|
GCNT3
|
2.93 ± 0.6*
|
3.73 ± 0.3*
|
5.90 ± 1.0*
|
4.29 ± 0.6*
|
|
GCNT4
|
2.92 ± 0.3*
|
2.33 ± 0.2*
|
3.02 ± 0.2*
|
3.14 ± 0.3*
|
|
C1GALT1
|
3.06 ± 0.6*
|
2.09 ± 0.2*
|
2.22 ± 0.5*
|
2.35 ± 0.2*
|
|
Backbone and terminal
| | | | |
|
GCNT2
|
2.87 ± 0.8*
|
1.60 ± 0.2
|
12.44 ± 4.2*
|
6.74 ± 1.0*
|
|
A4GNT
|
3.32 ± 0.3*
|
2.03 ± 0.3
|
3.12 ± 0.8*
|
2.75 ± 0.1*
|
|
B3GNT3
|
4.51 ± 1.1*
|
3.11 ± 0.6*
|
2.57 ± 0.8*
|
4.61 ± 0.4*
|
|
Sulfotransferases
| | | | |
|
H3ST1
|
1.14 ± 0.2*
|
2.10 ± 0.6*
|
4.52 ± 2.6*
|
2.35 ± 0.5*
|
|
H3ST2
|
n.d
|
n.d
|
n.d
|
n.d
|
|
GAL3ST1
|
n.d
|
n.d
|
n.d
|
n.d
|
|
Sialyltransferases
| | | | |
|
ST3GAL4
|
1.60 ± 0.1*
|
1.20 ± 0.2*
|
1.89 ± 0.3*
|
1.15 ± 0.1*
|
|
Fucosyltransferases
| | | | |
|
FUT1
|
1.94 ± 0.5*
|
1.27 ± 0.2*
|
0.77 ± 0.1*
|
1.33 ± 0.1*
|
|
FUT2
|
2.35 ± .4*
|
2.56 ± 0.8*
|
3.13 ± 0.4*
|
3.15 ± 0.2*
|
|
FUT4
|
2.77 ± 0.5*
|
2.89 ± 1.0*
|
3.09 ± 0.5*
|
3.13 ± 0.6*
|
|
FUT10
|
1.65 ± 0.2*
|
1.47 ± 0.2*
|
1.46 ± 0.2*
|
1.58 ± 0.1*
|
|
Disulphide isomerase
| | | | |
|
AGR2
|
3.41 ± 0.6*
|
3.44 ± 0.4*
|
5.82 ± 0.9*
|
5.24 ± 0.8*
|
|
PDIA3
|
3.16 ± 0.3*
|
2.60 ± 0.4*
|
4.12 ± 1.0*
|
4.46 ± 0.6*
|
|
PDIA4
|
2.58 ± 0.2*
|
3.51 ± 0.8*
|
6.95 ± 0.9*
|
5.37 ± 0.9*
|
-
a
- amean ± error standard of fold changes in infected animals compared to control (0 dpi).
- bdpi: days post-infection dpe: days post-exposure.
- cn.d.: not determined, too low in the sample.
- *p value ≤ 0.05 control 0 dpi vs infected animals (6, 9, 24 dpi; 60 dpe).
