Figure 3

Plaque latitude (L) and penetration depth underneath the basement membrane (D) of PRV(89V87) plaques at 20 h pi in mock-treated (white bars) and protease inhibitor-treated (marked bars) porcine nasal respiratory mucosa explants. Explants were mock-treated or treated with a trypsin-like serine protease inhibitor, Soybean Type I-S trypsin inhibitor, or with an elastase-like serine protease inhibitor, elastatinal, at 1 h pi, 3 h pi, 6 h pi, 9 h pi or 12 h pi until sampling. Data are represented as means of plaques observed in 120 sections (20 μm) of triplicate independent experiments + SD (error bars).