Genome sequence of Helicobacter suis supports its role in gastric pathology

Table 3 Homologs of H. pylori genes involved in induction of gastric lesions in the H. suis type strain 1 (HS1^T) and strain 5 (HS5) genome.

Gene detected in HS1^T	Gene detected in HS5	Gene name	Protein annotation/function in *H. pylori*	Sequence fraction HS1^T/HS5 aligned with *H. pylori* homolog (%)¹	Aligned sequence fraction HS1^T/HS5 conserved with *H. pylori* homolog (%)¹	References
HSUHS1_0989	HSUHS5_0761	vacA	Vacuolating cytotoxin A: host cell vacuolation, apoptosis-inducing, immunosuppresive	63/22	45/72	[46]
HSUHS1_0265	HSUHS5_0449	ggt	γ-glutamyl transpeptidase: apoptosis-inducing, immunosuppresive	99/99	86/86	[48, 49, 64]
HSUHS1_1177	HSUHS5_0014	napA	Neutrophil-activating protein A: proinflammatory	99/99	83/83	[50, 51]
HSUHS1_1067	HSUHS5_1177	fldA	Electron acceptor of the pyruvate oxidoreductase enzyme complex, associated with gastric MALT lymphoma in humans	96/98	84/83	[55, 56]
HSUHS1_0403	HSUHS5_0887	pgbA	Plasminogen-binding protein	60/60	72/72	[53, 54]
HSUHS1_1192	HSUHS5_0523	pgbB	Plasminogen-binding protein	70/70	72/72	[53, 54]

¹Resulting from tblastn-based cross-mapping of the H. pylori proteome to the H. suis HS1^T and HS5 genomes.

ISSN: 1297-9716