From: Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis
Description1 | Spots2 | O11 CDS3 | O46 CDS3 | ED133 CDS3 | pI4 | Mass (Da)5 | Score6 | Cov.7 | #pep.8 | EmPAI9 | Comp.10 | Loc.11 | Immun.12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Energy production and conversion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
formate acetyltransferase | 81, 83, 82 | 011_0041 | 046_0511 | SAOV_0163 | 5,31 | 84808 | 1301,60 | 34,31 | 22 | 1,57 | CW | C | Â |
ldh L-lactate dehydrogenase | 82, 99, 81, 83, 95 | 011_0136 | 046_0198 | SAOV_2646c | 4,80 | 34389 | 1749,37 | 63,64 | 26 | 21,75 | CW | C | [82] |
L-LACTATE DEHYDROGENASE (O11) | 64 | 011_0021 | 046_0531 | SAOV_0178 | 5,00 | 34548 | 745,83 | 50,79 | 14 | 2,59 | S | C | [82] |
bifunctional acetaldehyde-CoA/alcohol dehydrogenase | 79 | 011_0796 | 046_0709 | SAOV_0095 | 5,68 | 94945 | 2090,64 | 45,45 | 33 | 2,26 | CW | C | Â |
D-3-phosphoglycerate dehydrogenase | 100 | 011_0585 | 046_1131 | SAOV_2344 | 5,32 | 34652 | 717,85 | 43,53 | 11 | 1,72 | CW | C | Â |
atpD F0F1 ATP synthase subunit beta | 62, 90 | 011_2064 | 046_0898 | SAOV_2144c | 4,68 | 51368 | 631,03 | 30,21 | 10 | 0,98 | S,CW | C | [83] |
Nucleotide transport and metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
adk adenylate kinase | 9 | 011_0510 | 046_1206 | SAOV_2266c | 4,80 | 23375 | 531,72 | 42,38 | 9 | 2,80 | S | C | [84] |
deoD purine nucleoside phosphorylase | 9 | 011_1051 | 046_0577 | SAOV_2178 | 4,85 | 25892 | 470,94 | 53,39 | 8 | 1,97 | S | C | [4] |
guaB inositol-monophosphate dehydrogenase | 102, 129 | 011_0077 | 046_0960 | SAOV_0412 | 5,61 | 52818 | 1237,95 | 54,30 | 20 | 3,52 | CW,T | C | [4] |
Carbohydrate transport and metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 131 | 011_1952 | 046_0264 | SAOV_2463c | 5,23 | 26663 | 271.65 | 30.26 | 5 | 0.80 | S,T | C | Â |
eno enolase 2-phosphoglycerate dehydratase | 62, 88, 90, 96, 137 | 011_2336 | 046_2241 | SAOV_0818 | 4,55 | 47088 | 1868,52 | 63,59 | 25 | 7,09 | S,CW,T | C | |
fda fructose-1,6-bisphosphate aldolase | 107, 94, 72, 91, 95 | 011_0131 | 046_0202 | SAOV_2650 | 5,06 | 32878 | 852,09 | 46,62 | 13 | 2,48 | CW,S | C | |
gap glyceraldehyde-3-phosphate dehydrogenase | 99, 57, 81, 82, 83 | 011_2340 | 046_2237 | SAOV_0814 | 4,89 | 36258 | 940,06 | 46,13 | 13 | 3,04 | CW,S | C | |
putative translaldolase | 9 | 011_1872 | 046_2451 | SAOV_1765 | 4,72 | 25689 | 554,11 | 46,84 | 10 | 3,32 | S | C | Â |
tpiA triosephosphate isomerase | 9 | 011_2338 | 046_2239 | SAOV_0816 | 4,81 | 27271 | 1396,16 | 76,28 | 21 | 16,78 | S | C | |
atl autolysin | 23, 31 | 011_1991 | 046_0320 | SAOV_0999c | 9,59 | 136983 | 2567,68 | 42,14 | 42 | 1,87 | S | S | |
pyk pyruvate kinase | 105 | 011_1282 | 046_0580 | SAOV_1685 | 5,23 | 63067 | 271,45 | 11,62 | 5 | 0,29 | CW | C | [94] |
Lipid metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
fabZ 3R-hydroxymyristoyl ACP dehydratase | 126 | 011_2356 | 046_1839 | SAOV_2140c | 5,71 | 16071 | 86,65 | 13,70 | 2 | 0,47 | T | C | Â |
acetoin reductase | 106 | 011_1332 | 046_1393 | SAOV_0074 | 5,04 | 27199 | 566,84 | 40,31 | 7 | 1,82 | CW | C | Â |
Amino acid transport and metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
dipeptidase PepV | 62 | 011_1904 | 046_1329 | SAOV_1737 | 4,56 | 52762 | 235.33 | 10.66 | 4 | 0,27 | S | C | Â |
CYSTEINE SYNTHASE (O11) | 64 | 011_1382 | 046_2402 | SAOV_0535 | 5,38 | 32955 | 266.80 | 28.71 | 5 | 0,61 | S | C | Â |
Information storage and processing | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Translation, ribosomal structure and biogenesis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
fus elongation factor G | 95 | 011_0401 | 046_1769 | SAOV_0582 | 4,80 | 76564 | 2173,77 | 68,11 | 30 | 4,11 | CW | C | |
prs 50S ribosomal protein L25/general stress protein Ctc | 94 | 011_1370 | 046_2414 | SAOV_0523 | 4,39 | 23773 | 384,17 | 34,56 | 6 | 2,26 | CW,S | C | [95] |
rplC 50S ribosomal protein L3 | 131 | 011_0531 | 046_1185 | SAOV_2287c | 9,72 | 22648 | 482,78 | 42,11 | 9 | 2,95 | T | C | [95] |
rpsA 30S ribosomal protein S1 | 137, 62, 121, 171 | 011_2142 | 046_1743 | SAOV_1482 | 4,51 | 43252 | 1555,46 | 71,36 | 23 | 6,25 | S,CW,T | C | |
rpsD 30S ribosomal protein S4 | 139 | 011_1260 | 046_1365 | SAOV_1706 | 10,02 | 22999 | 428,22 | 40,50 | 8 | 1,96 | T | C | [95] |
rplB 50S ribosomal protein L2 | 91 | 011_0528 | 046_1188 | SAOV_2284c | 10,77 | 30136 | 239,93 | 25,27 | 5 | 0,69 | CW | C | [95] |
tsf elongation factor Ts | 100, 64 | 011_0909 | 046_0755 | SAOV_1259 | 5,05 | 32474 | 436,02 | 31,06 | 7 | 0,97 | CW,S | C | |
tuf elongation factor Tu | 90, 88, 96, 10, 122, 137, 149, 81, 82, 83, 95 | 011_0402 | 046_1768 | SAOV_0583 | 4,74 | 43077 | 2665,48 | 84,26 | 38 | 52,14 | S,CW,T | C | |
yfiA ribosomal subunit interface protein | 106 | 011_2483 | 046_1255 | SAOV_0789 | 5,25 | 21511 | 376,75 | 35,33 | 6 | 1,76 | CW | C | Â |
aspS aspartyl-tRNA synthetase | 63 | 011_2454 | 046_2303 | SAOV_1627 | 4,99 | 66584 | 233,90 | 7,65 | 4 | 0,21 | S | C | Â |
alaS alanyl-tRNA synthetase | 82 | 011_2466 | 046_2291 | SAOV_1616 | 5,00 | 98604 | 442,31 | 11,74 | 8 | 0,30 | O | C | [97] |
Transcription | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
nusA transcription elongation factor NusA | 62 | 011_0919 | 046_0765 | SAOV_1268 | 4,60 | 43701 | 247,74 | 11,00 | 4 | 0,34 | S | C | Â |
DNA replication, recombination and repair | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
dnaN DNA polymerase III subunit beta | 90 | 011_1166 | 046_1471 | SAOV_0002 | 4,66 | 41888 | 706,28 | 45,62 | 11 | 1,30 | CW | C | Â |
nuc staphylococcal thermonuclease precursor | 151, 108, 5, 153, 206, 207, 217 | 011_2070 | 046_2528 | SAOV_0832 | 9,20 | 25089 | 967,00 | 50,00 | 20 | 14,46 | S,CW | PSE | [98] |
ruvA Holliday junction DNA helicase | 66 | 011_2442 | 046_2315 | SAOV_1639 | 5,77 | 22249 | 137,72 | 17,00 | 3 | 0,52 | S | C | Â |
Posttranslational modification, protein turnover, chaperones | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
ahpC alkyl hydroperoxide reductase subunit C | 67, 82, 83, 99, 95 | 011_0085 | 046_0968 | SAOV_0404c | 4,88 | 20963 | 667,36 | 56,08 | 11 | 4,95 | S,CW | C | [93] |
AhpF ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (O11) | 97, 86 | 011_0086 | 046_0969 | SAOV_0403c | 4,68 | 54655 | 2242,14 | 67,06 | 34 | 9,91 | CW | C | Â |
dnaK chaperone protein | 96, 173, 137 | 011_2230 | 046_2216 | SAOV_1580 | 4,63 | 46021 | 2907,83 | 80,29 | 43 | 24,66 | S,CW,T | C | |
peptidyl-prolyl cis-isomerase | 212, 1, 68, 91 | 011_2089 | 046_2477 | SAOV_1837 | 9,01 | 35602 | 574,32 | 31,56 | 11 | 1,66 | S,CW | PSE | Â |
tig trigger factor | 105 | 011_1304 | 046_0602 | SAOV_1664 | 4,34 | 48565 | 1061,87 | 61,43 | 17 | 2,25 | CW | C | [94] |
TrxB THIOREDOXIN REDUCTASE (O11) | 64 | 011_2580 | 046_2228 | SAOV_0801 | 5,21 | 33595 | 681,95 | 33,76 | 11 | 1,81 | S | C | [93] |
Cellular processes | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Cell envelope biogenesis, outer membrane | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
IsaA IMMUNODOMINANT ANTIGEN A (O46) | 185, 8, 161, 186, 9, 164, 189 | 011_0168 | 046_0166 | SAOV_2614c | 5,91 | 24219 | 1516,56 | 59,23 | 22 | 40,99 | S | S | |
isdA iron-regulated cell wall-anchored protein | 31, 27, 73, 74, 75, 83, 118, 79, 81, 82, 95 | 011_1476 | 046_1296 | SAOV_1125c | 8,69 | 70445 | 2288,12 | 57,87 | 38 | 6,04 | S,CW | PSE | |
isdB cell surface transferrin-binding protein | 212, 211, 210, 208, 193, 156, 138, 110, 70, 86, 131, 156, 193 | 011_1477 | 046_1295 | SAOV_1126c | 9,54 | 39197 | 886,30 | 45,48 | 15 | 4,45 | S,CW,T | PSE | |
IRON-REGULATED SURFACE DETERMINANT PROTEIN H (O11) | 55, 31 | 011_1248 | 046_1353 | SAOV_1717 | 5,05 | 100650 | 2209,72 | 42,11 | 37 | 2,58 | S | PSE | [75] |
IsdD iron-regulated protein | 15, 16 | 011_1480 | 046_1292 | SAOV_1128 | 8,51 | 41357 | 278,05 | 15,36 | 5 | 0,47 | S | PSE | Â |
Cell motility and secretion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
N-acetylmuramoyl-L-alanine amidase | 52, 51, 187 | 011_1090 | 046_1546 | SAOV_2693 | 5,87 | 69226 | 3097,93 | 71,57 | 43 | 16,52 | S | S | |
Inorganic ion transport and metabolism | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
nasE assimilatory nitrite reductase | 10 | 011_1932 | 046_0245 | SAOV_2445c | 4,95 | 11430 | 126,05 | 23,08 | 2 | 0,70 | S | C | Â |
mntC Manganese/iron transport system substrate-binding protein | 94 | 011_2274 | 046_0062 | SAOV_0666c | 8,68 | 34719 | 1183,08 | 51,46 | 20 | 10,68 | S,CW | PSE | Â |
sirA iron-regulated lipoprotein | 135, 64 | 011_1345 | 046_1405 | SAOV_0062 | 9,20 | 36735 | 609,79 | 35,45 | 11 | 1,58 | S,T | PSE | [104] |
fhuD2 ferrichrome-binding protein | 91 | 011_0566 | 046_1150 | SAOV_2323c | 9,16 | 33990 | 406,75 | 30,13 | 8 | 1,10 | CW | PSE | [105] |
ferrichrome ABC transporter lipoprotein | 91 | 011_1857 | 046_1674 | SAOV_2224c | 9,44 | 36751 | 600,45 | 38,41 | 11 | 1,57 | CW | PSE | Â |
Signal transduction mechanisms | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
SA1540 GAF domain-containing protein | 10 | 011_1261 | 046_1366 | SAOV_1705 | 5,09 | 17042 | 139,34 | 22,73 | 3 | 0,72 | S | C | Â |
Universal stress response protein | 7, 123 | 011_1269 | 046_1374 | SAOV_1697 | 5,60 | 18463 | 973,68 | 78,31 | 12 | 19,34 | S,CW | C | [106] |
Toxins and haemolysins | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
beta-hemolysin | 15, 19, 205 | 011_1750 | 046_2394 | SAOV_2040 | 8,75 | 37386 | 1308,79 | 61,03 | 20 | 4,92 | S | S | |
hla alpha-hemolysin precursor | 13, 1, 15, 19, 21, 68, 72, 107, 146, 153 | 011_1514 | 046_1259 | SAOV_1161c | 8,87 | 36329 | 2238,72 | 76,71 | 34 | 44,90 | S,CW,T | S | |
hlgC gamma-hemolysin component C | 68, 1 | 011_1956 | 046_0268 | SAOV_2469 | 9,29 | 35562 | 765,07 | 31,43 | 12 | 1,90 | S,CW | S | [57] |
Virulence/defence mechanisms | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Sbi IGG-BINDING PROTEIN SBI (O11) | 216, 217, 212 | 011_1954 | 046_0266 | SAOV_2466 | 9,38 | 49998 | 984,16 | 41,74 | 18 | 2,80 | S | S | [76] |
SspB CYSTEINE PROTEASE PRECURSOR (O11) | 58, 57, 64, 182, 215 | 011_2154 | 046_0327 | SAOV_0993c | 5,45 | 42714 | 2027,86 | 65,52 | 30 | 11,52 | S | S | [4] |
SplF serine proteinase | 4 | 011_0672 | 046_2496 | SAOV_1795 | 9,36 | 25638 | 255,88 | 23,01 | 5 | 0,84 | S | S | [108] |
lukD leukotoxin D subunit | 1 | 011_0685 | 046_2484 | SAOV_1812 | 9,14 | 36936 | 365,37 | 22,02 | 7 | 0,98 | S | S | [109] |
lukE leukotoxin E subunit | 1, 68 | 011_0686 | 046_2483 | SAOV_1813c | 9,38 | 34126 | 451,11 | 17,65 | 7 | 1,77 | S,CW | S | [109] |
leukocidin chain lukM precursor | 68, 1, 120, 145, 177, 194, 201, 202, 94 | 011_1215 | 046_2777 | SAOV_1909 | 9,41 | 35054 | 2504,69 | 71,43 | 35 | 29,80 | S,CW,T | S | |
leukocidin F subunit | 16, 70 | 011_1752 | 046_1972 | SAOV_2041 | 8,29 | 38639 | 1154,65 | 45,27 | 19 | 11,64 | S,CW | S | |
leukocidin S subunit | 199, 5, 70, 108, 109, 197, 200, 211 | 011_1753 | 046_1973 | SAOV_2042 | 9,38 | 40379 | 1399,91 | 55,56 | 23 | 6,70 | S,CW | S | |
Panton-Valentine leukocidin LukF-PV chain precursor | 1, 68, 70, 15, 31, 119, 195, 203, 204, 10, 91 | 011_1216 | 046_2776 | SAOV_1908 | 9,16 | 36496 | 965,38 | 50,31 | 15 | 3,37 | S,CW | S | |
plc 1-phosphatidylinositol phosphodiesterase | 11, 12, 19 | 011_1424 | 046_1419 | SAOV_0049 | 7,12 | 37030 | 2759,20 | 71,95 | 44 | 84,00 | S | S | [4] |
Aur ZINC METALLOPROTEINASE AUREOLYSIN (O11) | 220, 63 | 011_1083 | 046_1553 | SAOV_2686c | 4,98 | 54947 | 921,93 | 47,39 | 17 | 1,68 | S | C | |
Opp1A OLIGOPEPTIDE TRANSPORTER SUBSTRATE BINDING PROTEIN (O11) | 86 | 011_2424 | 046_2102 | SAOV_2517c | 8,33 | 59224 | 1398,01 | 47,53 | 24 | 3,28 | CW | PSE | Â |
SspA GLUTAMYL ENDOPEPTIDASE SERINE PROTEASE (O11) | 56, 184, 214 | 011_2155 | 046_0325 | SAOV_0994c | 4,68 | 32250 | 1575,55 | 69,26 | 24 | 24,18 | S | C | [57] |
SECRETED VON WILLEBRAND FACTOR-BINDING PROTEIN (O11) | 22 | 011_2679 | 046_0987 | SAOV_2051c | 8,39 | 57935 | 1122,89 | 36,67 | 17 | 1,70 | S | S | Â |
epidermal cell differentiation inhibitor B | 208, 209, 193, 156, 4 | 011_0489 | 046_2741 | Â | 9,51 | 27969 | 1385,18 | 69,32 | 22 | 22,31 | S | S | Â |
Miscellaneous | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
adhA alcohol dehydrogenase | 100 | 011_1554 | 046_0086 | SAOV_0640 | 5,34 | 36025 | 1167,82 | 66,37 | 16 | 4,30 | CW | C | |
exported secretory antigen precursor | 67 | 011_0584 | 046_1132 | SAOV_2343 | 5,77 | 17388 | 397,17 | 33,13 | 5 | 1,43 | S | S | Â |
lip triacylglycerol lipase precursor | 31, 27 | 011_1119 | 046_1518 | SAOV_2721c | 8,13 | 76637 | 1723,17 | 50,95 | 29 | 2,36 | S | S | [93] |
mqo malate:quinone oxidoreductase | 128 | 011_0130 | 046_0203 | SAOV_2651c | 6,12 | 55964 | 1047,99 | 46,79 | 17 | 2,50 | T | C | Â |
putative staphylococcal enterotoxin | 151 | 011_0097 | 046_0981 | SAOV_0394 | 9,54 | 23311 | 173,20 | 18,72 | 4 | 0,71 | S | S | Â |
Unknown | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
HYPOTHETICAL PROTEIN (O11) | 220 | 011_0736 | 046_1969 | SAOV_0454 | 4,89 | 56229 | 823,11 | 39,40 | 14 | 1,21 | S | S | Â |
hypothetical protein (Similar to truncated map-w protein (91%)) | 88, 10, 62 | 011_1749 | 046_2393 | Â | 9,91 | 53686 | 899,64 | 34,52 | 18 | 2,09 | S,CW | S | [112] |
hypothetical protein (Similar to beta-lactamase (84%)) | 10 | 011_0679 | 046_2490 | Â | 6,84 | 20800 | 726,52 | 47,15 | 10 | 7,09 | S | S | Â |
HYPOTHETICAL PROTEIN (O46) | 157, 160, 175, 189, 193 | 011_0490 | 046_2740 | Â | 8,88 | 30854 | 2343,27 | 74,29 | 41 | 65,07 | S | S | Â |
hypothetical protein (Similar to probable glutamyl-endopeptidase (76%)) | 66 | 011_0488 | 046_2742 | Â | 5,44 | 20552 | 741,93 | 47,62 | 12 | 5,11 | S | C | Â |
SA0570 HYPOTHETICAL PROTEIN (O46) | 219,154, 127 | 011_2290 | 046_0078 | SAOV_0649 | 9,17 | 18554 | 815,59 | 69,05 | 13 | 15,93 | S,CW | S | Â |
SA0663 hypothetical protein | 10, 164, 94 | 011_2561 | 046_2636 | SAOV_0742c | 9,15 | 16047 | 457,11 | 35,62 | 8 | 3,63 | S | PSE | Â |
SA0914 hypothetical protein | 6 | 011_2000 | 046_0311 | SAOV_1008c | 6,55 | 11338 | 522,48 | 57,14 | 8 | 13,10 | S | S | Â |
pathogenicity island protein | 55 | 011_2741 | 046_0985 | SAOV_0429 | 9,55 | 12071 | 204,61 | 19,64 | 3 | 1,12 | S | S | Â |
SA1607 hypothetical protein | 91 | 011_1867 | 046_2456 | SAOV_1770 | 6,04 | 34973 | 232,41 | 16,56 | 4 | 0,43 | CW | S | Â |
SA1402 hypothetical protein | 91 | 011_2223 | 046_2209 | SAOV_1573 | 5,60 | 35160 | 448,93 | 28,27 | 6 | 0,72 | CW | S | Â |