A. Changes in coding sequences | ||||
---|---|---|---|---|
Gene (according to NC_003663) | Function | Modification (nt position) | Present in parental virus | Effect |
006 | ankyrina | C to A (5 038) | no | silent |
019 | ankyrin | C to T (21 015) | yes | Glu to Lys, not in ankyrin repeats |
035 | kelch-like | ins. T (36 656) | yes | split protein, resembles situation in other orthopox viruses |
079 | glutaredoxin (GRX) family | C to T (76 314) | yes | Asp to Asn, polymorphic region of the protein |
089 | protein G1 (Peptidase) | T to C (87 650) | yes | Asn to Asp, like in 91-3 |
105 | tk | T to C (97 522) | no | silent, PCR error |
106 | polyA polymerase small SU | (105 299) | no | silent, PCR error |
139 | poxvirus early transcription factor (VETF) | Insertion : T (142 924) | yes | C-terminal amino acid sequence changed from RAQIN to KSTNKLNN |
193 | kelch-like | C to T (189 440) | yes | Ser to Phe, polymorphic region of the protein |
215 | kelch-like | C to T (213 275) | yes | Pro to Ser, polymorphic region of the protein |
225 | ankyrina | G to T (229 788) | no | silent |
B. Changes in non-coding sequences | ||||
Modification (nt position) | Comment | |||
Insertion : TG (8 899-8 900)b | poly-TG repeat, polymorphic in viral DNA | |||
C to T (58 974) | ||||
Insertion : T (65 922) | poly-T stretch | |||
Insertion : CA (225 926-225 927)b | poly-CA repeat, polymorphic in viral DNA | |||
Insertion : TG (8 899-8 900)b | poly-TG repeat, polymorphic in viral DNA |