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Table 1 Specific infectivity of FMDV RNA of different lymphoid tissues

From: A replication analysis of foot-and-mouth disease virus in swine lymphoid tissue might indicate a putative carrier stage in pigs

  Tonsil Spleen Thymus ING RTF MED MES PRE
1 NDa (+++)b ND (+) ND (-) ND (-) ND (-) ND (-) ND (-) 5 × 10-7
  6 × 10-4 c ND (+) ND (+) ND (-) ND (+) ND (-) ND (-) 7 × 10-8
2 ND (+) 2 × 10-4 7 × 10-5 1 × 10-4 ND (+) ND (+) 1 × 10-5 5 × 10-6
  2 × 10-7 2 × 10-5 4 × 10-6 1 × 10-6 ND (+) ND (+++) ND (+++) 2 × 10-6
3 2 × 10-4 ND (+++) 2 × 10-5 ND (++) 1 × 10-7 4 × 10-4 ND (+++) ND (+)
  5 × 10-4 ND (+++) ND (++) ND (+) ND (++) ND (+++) ND (+++) ND (-)
  3 × 10-7 ND (+++) ND (++) ND (++) ND (+) ND (+++) ND (+++) ND (+)
7 2 × 10-7 ND (+++) ND (+++) ND (+++) ND (++) ND (+++) ND (+++) ND (+)
  ND (++) ND (+++) ND (+++) ND (+++) ND (++) ND (+++) ND (+++) ND (+++)
14 7 × 10-6 ND (+++) ND (+++) ND (+++) ND (+++) ND (+++) ND (+++) ND (+++)
  1 × 10-5 ND (+++) ND (++) ND (++) ND (+++) ND (+++) ND (+++) ND (+++)
17 ND (+++) ND (+++) ND (+++) ND (+++) ND (+) ND (+++) ND (+++) ND (+)
  1. It is indicated the specific infectivity of FMDV RNA at different times post-inoculation (right columna) from tonsil, spleen, thymus and several lymph nodes [inguinal (ING), retropharyngeal (RTF), mediastinal (MED), mesenteric (MES), and prescapular (PRES)].
  2. a ND: not determined.
  3. b Cythopatic effect: BHK-21 cells were infected with homogenate from tissues and cytophatic effect (cpe) was evaluated at 48 h post-infection. (-), no cpe; (+), 10-20% of cpe; (++) 50% of cpe; (+++) 100% cpe.
  4. c Specific infectivity is expressed as the number of PFU per viral RNA molecule.