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Table 1 Overview concerning anamnestic data of the cows and immunohistochemical results of all samples examined

From: BSE infectivity in jejunum, ileum and ileocaecal junction of incubating cattle

Months p.i. Cow Status PrPSc in the Obex (IHC) Ileum Ileocaec.-junct. Jejunum
     No. pos. Foll./Total No. Foll. No. pos. Foll. in % TBM/Intracellular Reaction Pattern FDC ENS No. pos. Foll./Total No. Foll. No. pos. Foll./Total No. Foll.
1 (n = 3) IT 04 preclinical negative 0/9189 0 -- -- -- 0/3289 0/1337
  IT 44 preclinical negative 0/6272 0 -- -- -- 0/912 0/761
  IT 62 preclinical negative 0/4634 0 -- -- -- 0/721 0/9479
4 (n = 2) IT 19 preclinical negative 1/4076 0.02 punctate -- -- 0/102 0/848
  IT 45 preclinical negative 4/4399 0.09 punctate -- -- 0/162 0/1453
  IT 14 preclinical negative 0/726 0 -- -- -- 0/394 0/1256
8 (n = 4) IT 20 preclinical negative 15/2554 0.6 punctate/fine granular -- -- 0/1037 0/2636
  IT 39 preclinical negative 1/1309 0.07 punctate -- -- 0/601 0/457
  IT 55 preclinical negative 1/2285 0.04 punctate -- -- 0/279 0/475
12 (n = 4) IT 01 preclinical negative 89/461 19.3 punctate/fine granular (+)* -- 0/352 0/437
  IT 16 preclinical negative 3/1711 0.2 punctate -- -- 0/1252 0/1135
  IT 06 preclinical negative 56/957 5.8 fine granular/globular (+)* --. 3/418 0/201
  IT 57 preclinical negative 65/1384 4.7 fine granular/globular (+)* -- 0/1251 0/495
16 (n = 4) IT 07 preclinical negative 0/135 0 -- -- -- 0/909 0/325
  IT 28 preclinical negative 4/1514 0.3 fine granular/globular + + 6/1149 0/550
  IT 46 preclinical negative 0/708 0 -- -- -- 0/510 0/970
  IT 65 preclinical negative 8/2483 0.3 fine granular (+) -- 0/975 0/1112
20 (n = 4) IT 10 preclinical negative 0/774 0 -- -- -- 0/580 0/1187
  IT 17 preclinical negative 1/1369 0.07 fine granular/globular -- -- 26/1456 0/1004
  IT 50 preclinical negative 1/611 0.2 globular -- -- 0/449 0/712
  IT 60 preclinical negative 2/902 0.2 fine granular/globular + -- 0/699 0/265
24 (n = 4) IT 26 preclinical positive 35/389 9.0 globular + +++ 0/819 0/996
  IT 24 preclinical negative 29/438 6.6 globular + + 0/1037 0/1999
  IT 47 preclinical negative 89/343 25.9 fine granular (+) + 0/511 0/1114
  IT 58 preclinical negative 0/86 0 -- -- -- 4/1027 0/1473
28 (n = 4) IT 08 preclinical positive 6/508 1.2 fine granular (+) + 0/182 n.d.
  IT 21 preclinical positive 4/489 0.8 fine granular -- -- n.d. n.d.
  IT 51 preclinical negative 1/854 0.1 fine granular -- -- 0/669 n.d.
  IT 52 preclinical negative 2/1574 0.1 punctate -- -- n.d. n.d.
32 (n = 4) IT 05 preclinical positive 0/114 0 -- -- + 0/1278 n.d.
  IT 09 clinical positive 10/54 18.5 fine granular/globular + +++ n.d. n.d.
  IT 43 clinical positive 11/694 1.6 fine granular/globular (+) -- 0/569 n.d.
  IT 61 clinical positive 7/291 2.4 fine granular/globular (+) -- n.d. n.d.
36 (n = 4) IT 49 clinical positive 12/314 3.8 fine granular (+) + n.d. n.d.
  IT 48 preclinical negative 2/473 0.4 globular -- -- 0/1306 n.d.
  IT 11 clinical positive 0/349 0 -- -- ++ n.d. n.d.
  IT 23 clinical positive 14/177 7.9 globular + +++ 0/602 n.d.
40 (n = 4) IT 13 clinical positive 15/385 3.9 fine granular/globular (+)* ++ 0/750 n.d.
  IT 25 clinical positive 0/45 0 -- -- ++ n.d. n.d.
  IT 56 preclinical positive 1/661 0.2 fine granular -- + n.d n.d.
  IT 41 preclinical positive 0/112 0 -- -- +++ 0/564 n.d.
44 (n = 4) IT 15 clinical positive 1/121 0.8 fine granular -- + 0/546 453
  IT 22 clinical positive 0/215 0 -- -- +++ n.d. n.d.
  IT 02 clinical positive 0/131 0 -- -- ++ 1*/724 859
  IT 53 clinical positive 3/480 0.6 fine granular/globular -- + 0/690 1390
  IT 38 clinical positive 0/155 0 -- -- -- n.d. n.d.
  1. TBM: Tingible Body Macrophages, n.d.: not done, * only seen with mab 6C2, pos: positive, Foll: Follicle
  2. ENS: total number of positive labelled foci in the ENS (submucosal and myenteric plexuses), +:0-4 positive foci in the ENS, ++: 5-10 positive foci in the ENS, +++: > 11 positive foci in the ENS
  3. FDC: (+): weak dendritic network, +: clear dendritic network