4 hours post infection with S. Enteritidis | 24 hours post infection with S. Enteritidis | |||||
---|---|---|---|---|---|---|
wt | ΔSPI1 | n.i. | wt | ΔSPI1 | n.i. | |
IL-1β | 74.3 ± 59.7 | 187.5 ± 163.1** | 0.62 ± 0.28** | 36.8 ± 13.6 | 238.5 ± 224.5* | 0.20 ± 0.19* |
IL-8 | 15.7 ± 3.7 | 23.4 ± 9.4 | 0.92 ± 0.57** | 5.5 ± 4.7 | 17.5 ± 6.4 | 0.19 ± 0.18** |
TNFα | 57.9 ± 54.9 | 113.8 ± 105.1** | 1.1 ± 1.0** | 9.6 ± 7.1 | 15.6 ± 17.0 | 0.20 ± 0.07** |
IL-23α | 7.6 ± 5.3 | 30.5 ± 22.6** | 0.05 ± 0.02** | 4.7 ± 2.6 | 83.1 ± 82.8* | 0.014 ± 0.007** |
IL-12β | 0.025 ± 0.026 | 0.043 ± 0.038 | 0.0008 ± 0.0001* | 0.29 ± 0.31 | 3.01 ± 3.63** | 0.0009 ± 0.0005** |
TGFβ | 18.6 ± 6.4 | 18.7 ± 6.8 | 11.2 ± 2.1 | 15.2 ± 7.2 | 25.4 ± 18.3 | 12.3 ± 5.6 |
IL-18 | 0.56 ± 0.34 | 0.72 ± 0.39* | 0.16 ± 0.08 | 0.66 ± 0.38 | 1.13 ± 0.49 | 0.60 ± 0.58 |
GM-CSF | 0.19 ± 0.15 | 0.32 ± 0.19* | 0.02 ± 0.03** | 0.37 ± 0.27 | 1.92 ± 1.64** | 0.015 ± 0.020** |
IL-6 | 0.27 ± 0.37 | 0.92 ± 1.35 | 0.0012 ± 0.0011 | 0.23 ± 0.34 | 1.79 ± 2.88* | n.d. |
NRAMP1 | 36.8 ± 20.0 | 32.9 ± 21.1 | 25.8 ± 12.9* | 29.6 ± 17.1 | 67.9 ± 48.5* | 18.0 ± 7.7 |
SOD1 | 5.9 ± 2.5 | 6.3 ± 3.0 | 4.9 ± 2.3 | 3.7 ± 1.6 | 7.5 ± 5.5 | 3.4 ± 1.4 |
phox47 | 4.7 ± 1.4 | 6.5 ± 1.7* | 5.5 ± 1.7 | 2.9 ± 0.5 | 4.2 ± 1.1* | 4.2 ± 2.0 |
iNOS | 0.012 ± 0.005 | 0.064 ± 0.035** | 0.0015 ± 0.0004** | 0.0055 ± 0.0061 | 0.026 ± 0.039 | 0.0025 ± 0.0006 |