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Table 2 Prnp genotype frequencies [%] of scrapie cases and control goats.

From: Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom

Herd
Genotype
A
Gp1
Scr+
A
Gp2
Scr+
B
Gp1
Scr+
B
Gp2
Scr+
A
Gp1/2
Scr+
B
Gp1/2
Scr+
E
Scr+
B
Scr-
A&
Scr-
A$
cl. Scr-
E*
cl.
Scr-
wt-S/wt-S 6 3 0 0 4.6 0 0 0 2.3 6.6 0
wt-P/wt-S 34.8 12.3 11.1 0 23.7 6.3 66.7 1.3 4.6 21.7 12
wt-P/wt-P 43.9 21.5 77.8 57.1 32.8 68.7 33.3 24.6 12.5 21.2 22
wt-P/S127 1.5 4.6 11.1 42.9 3.1 25 0 28.3 8.6 6 3.3
wt-S/S127 0 7.7 0 0 3.9 0 0 1.9 0.8 2 0
S127/S127 0 0 0 0 0 0 0 5 0 0 0
S127/M142 0 1.6 0 0 0.8 0 0 11.9 2.3 3 3.3
wt-P/M142 10.6 29.3 0 0 19.7 0 0 20.1 30.5 19.7 31.9
wt-S/M142 1.6 15.4 0 0 8.4 0 0 0.6 16.4 7 7.7
M142/M142 0 3 0 0 1.5 0 0 5 17.2 7.6 9.9
R101 carrier 0 0 0 0 0 0 0 1.2 0 0 0
Q211 carrier 0 0 0 0 0 0 0 0 3.2 2.5 3.4
K222 carrier 0 0 0 0 0 0 0 0 0.8 1 5.5
Partial^ 1.6 1.6 0 0 1.6 0 0 0 0.8 1.6 1.1
Total (n) 66 65 9 7 131 16 3 159 128 198 91
  1. Legend: For allele abbreviation see Figure 1. Scr = scrapie; cl = clinical; for definition of group-1 (Gp1) and group-2 (Gp2) see main text, in short: group-1 clinical positive and fallen stock goats, group-2 pre-clinical, PrPd positive goats; Gp1/2 = Gp1+Gp2; ^partial here means one allele in heterozygote could not be unambiguously identified for all positions; &scrapie-free goats, clinically and PrPd negative; $clinically negative goats, randomly selected goats of which approx. 1/3 were tested and found negative for PrPd; *randomly selected clinically negative herd-mates, not tested for PrPd.