|  |  | Fold changes and p-values |  | ||||
---|---|---|---|---|---|---|---|---|
Functional group | Gene symbol | Gene description | 1 dpi | 60 dpi | 120 dpi | 270 dpi | p -value | Previous prion gene expression studies on the Central Nervous System |
Immune, inflammatory and stress response | Cxcl13 | chemokine (C-X-C motif) ligand 13 | 1.59 | 0.91 | 0.90 | 30.48 | < 1.00E-04 | |
 | Clec7a | C-type lectin domain family 7, member a | 1.00 | 1.02 | 0.90 | 3.56 | < 1.00E-04 | |
 | Cybb | cytochrome b-245, beta polypeptide | 1.14 | 1.33 | 0.84 | 2.87 | < 1.00E-04 | [37] (S) |
 | C4 | complement component 4 (within H-2S) | 0.95 | 1.17 | 0.88 | 2.77 | < 1.00E-04 | |
 | Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 0.82 | 0.85 | 0.56 | 2.50 | < 1.00E-04 | |
 | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | 0.97 | 0.52 | 1.34 | 2.37 | 4.00E-04 |  |
 | C3 | complement component 3 | 0.90 | 1.12 | 0.93 | 2.35 | 2.00E-04 | |
 | C1qb | complement component 1, q subcomponent, beta polypeptide | 1.02 | 0.91 | 0.94 | 2.20 | < 1.00E-04 | [27] (S), [18] (S), [28] (S), [19] (S), [9] (S), [12] (S), [32, 34] (S/CJD) |
 | C1qa | complement component 1, q subcomponent, alpha polypeptide | 1.04 | 1.01 | 0.98 | 2.14 | < 1.00E-04 | |
 | C1qg | complement component 1, q subcomponent, gamma polypeptide | 1.07 | 0.88 | 0.88 | 2.14 | < 1.00E-04 | |
 | Osmr | oncostatin M receptor | 0.82 | 1.08 | 0.97 | 2.13 | < 1.00E-04 | |
 | C3ar1 | complement component 3a receptor 1 | 0.72 | 1.02 | 0.99 | 2.03 | < 1.00E-04 | |
 | Cd14 | CD14 antigen | 0.88 | 0.96 | 0.95 | 1.93 | < 1.00E-04 | |
 | Mpeg1 | macrophage expressed gene 1 | 0.87 | 1.09 | 0.94 | 1.90 | 1.00E-04 | |
 | Lilrb4 | leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 0.67 | 0.92 | 1.10 | 1.90 | 5.00E-04 |  |
 | Ly86 | lymphocyte antigen 86 | 1.11 | 0.94 | 0.88 | 1.88 | < 1.00E-04 | |
 | Tlr2 | toll-like receptor 2 | 0.97 | 1.12 | 0.93 | 1.84 | < 1.00E-04 | |
 | Hspb6 | heat shock protein, alpha-crystallin-related, B6 | 0.98 | 1.03 | 1.10 | 1.82 | < 1.00E-04 |  |
 | Cd48 | CD48 antigen | 0.82 | 0.89 | 0.88 | 1.81 | < 1.00E-04 | [18] (S) |
 | Icsbp1 | interferon consensus sequence binding protein 1 | 0.91 | 1.02 | 0.95 | 1.76 | < 1.00E-04 | |
 | Ifi27 | interferon, alpha-inducible protein 27 | 0.97 | 0.96 | 0.89 | 1.75 | 6.00E-04 |  |
 | Usp18 | ubiquitin specific peptidase 18 | 0.87 | 1.04 | 0.80 | 1.72 | 3.00E-04 | [37] (S) |
 | Socs3 | suppressor of cytokine signaling 3 | 0.78 | 0.86 | 0.90 | 1.72 | 7.00E-04 | [18] (S) |
 | Dusp1 | dual specificity phosphatase 1 | 1.38 | 0.65 | 0.73 | 0.50 | 1.00E-04 | [38] (S) |
 | Map4k2 | mitogen activated protein kinase kinase kinase kinase 2 | 0.98 | 1.25 | 0.90 | 0.44 | 1.00E-04 |  |
 | Mamdc1 (Mdga2 VALIDATED)) | MAM domain containing 1 (MAM domain containing glycosylphosphatidylinositol anchor 2 (VALIDATED)) | 0.44 | 2.21 | 0.40 | 0.25 | 0.001 |  |
Glial response | Gfap | glial fibrillary acidic protein | 0.89 | 1.06 | 0.99 | 3.37 | < 1.00E-04 | [85] (S), [86] (S/AD) [18] (S), [19] (S), [28] (S), [30] (CJD), [12] (S), [31] (S), [34] (S/CJD), [35] (S), [37] (S) |
 | Cst7 | cystatin F (leukocystatin) | 0.99 | 1.08 | 0.97 | 3.24 | < 1.00E-04 | |
 | Lgals3 | lectin, galactose binding, soluble 3 | 0.57 | 1.10 | 0.78 | 2.65 | < 1.00E-04 | |
 | Cd68 | CD68 antigen | 0.80 | 0.99 | 0.82 | 2.04 | < 1.00E-04 | |
 | Tyrobp | TYRO protein tyrosine kinase binding protein | 1.02 | 1.04 | 0.84 | 1.99 | < 1.00E-04 | |
 | Mt2 | metallothionein 2 | 0.84 | 1.14 | 1.43 | 1.86 | < 1.00E-04 | |
Cell death | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | 0.97 | 0.52 | 1.34 | 2.37 | 4.00E-04 | Â |
 | Ctsc | cathepsin C | 0.96 | 0.81 | 1.05 | 1.81 | < 1.00E-04 | |
 | Bcl2a1a | B-cell leukemia/lymphoma 2 related protein A1a | 1.01 | 0.97 | 1.01 | 1.70 | 6.00E-04 | |
 | 1110006I15Rik (tmem109 (PROVISIONAL)) | RIKEN cDNA 1110006I15 gene (transmembrane protein 109 (PROVISIONAL)) | 0.80 | 1.29 | 1.40 | 0.56 | 5.00E-04 |  |
 | AA536749 (mprip VALIDATED)) | expressed sequence AA536749 (myosin phosphatase Rho interacting protein (VALIDATED)) | 0.85 | 1.45 | 1.02 | 0.53 | 3.00E-04 |  |
 | Nr4a1 | nuclear receptor subfamily 4, group A, member 1 | 1.53 | 0.65 | 0.68 | 0.49 | < 1.00E-04 | |
Cell adhesion | Cd44 | CD44 antigen | 0.87 | 0.92 | 0.82 | 2.13 | 1.00E-04 | |
 | Itgax | integrin alpha X | 0.95 | 1.06 | 0.89 | 1.79 | < 1.00E-04 | |
 | Gpnmb | glycoprotein (transmembrane) nmb | 0.71 | 1.08 | 1.01 | 1.74 | 9.00E-04 | |
 | Ptprd | protein tyrosine phosphatase, receptor type, D | 0.93 | 2.67 | 0.75 | 0.39 | 1.00E-04 |  |
Intracellular transport | Snx6 | sorting nexin 6 | 1.61 | 0.69 | 1.32 | 2.24 | 4.00E-04 | Â |
 | Ndel1 | nuclear distribution gene E-like homolog 1 (A. nidulans) | 1.06 | 0.56 | 0.96 | 2.11 | 1.00E-04 |  |
 | Snx14 | sorting nexin 14 | 0.83 | 0.78 | 1.16 | 1.84 | < 1.00E-04 |  |
 | Vps37c | vacuolar protein sorting 37C (yeast) | 0.82 | 1.03 | 1.21 | 0.55 | < 1.00E-04 |  |
 | Scfd1 | sec1 family domain containing 1 | 0.62 | 1.51 | 0.67 | 0.52 | 4.00E-04 |  |
 | Rtn3 | reticulon 3 | 0.85 | 1.66 | 0.96 | 0.34 | < 1.00E-04 | |
Transmission of nerve impulse | Tyrobp | TYRO protein tyrosine kinase binding protein | 1.02 | 1.04 | 0.84 | 1.99 | < 1.00E-04 | |
 | Slc6a4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 1.12 | 1.62 | 0.99 | 0.60 | 0.0012 |  |
 | Arc | activity regulated cytoskeletal-associated protein | 2.20 | 0.66 | 0.96 | 0.45 | < 1.00E-04 |  |
 | Pmch | pro-melanin-concentrating hormone | 0.98 | 1.27 | 0.83 | 0.44 | < 1.00E-04 |  |
 | Egr2 | early growth response 2 | 1.58 | 0.49 | 0.56 | 0.36 | 1.00E-04 |  |
 | Scn2b | sodium channel, voltage-gated, type II, beta | 0.96 | 1.57 | 0.97 | 0.09 | < 1.00E-04 |  |
Signal transduction | S100a6 | S100 calcium binding protein A6 (calcyclin) | 0.92 | 0.93 | 0.89 | 1.93 | < 1.00E-04 | |
 | Hpgd | hydroxyprostaglandin dehydrogenase 15 (NAD) | 0.86 | 0.98 | 0.95 | 1.93 | < 1.00E-04 | [37] (S) |
 | Adamts4 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 | 0.55 | 1.25 | 0.81 | 0.60 | 4.00E-04 |  |
 | Nr4a1 | nuclear receptor subfamily 4, group A, member 1 | 1.53 | 0.65 | 0.68 | 0.49 | < 1.00E-04 | |
 | Ptprd | protein tyrosine phosphatase, receptor type, D | 0.93 | 2.67 | 0.75 | 0.39 | 1.00E-04 |  |
Transcription | Npas3 | neuronal PAS domain protein 3 | 1.80 | 0.57 | 1.64 | 2.42 | 4.00E-04 | Â |
 | Tle4 | transducin-like enhancer of split 4, homolog of Drosophila E(spl) | 0.97 | 0.91 | 0.79 | 1.99 | < 1.00E-04 |  |
 | Cbx7 | chromobox homolog 7 | 0.93 | 0.87 | 1.19 | 1.96 | 4.00E-04 |  |
 | Smad4 | MAD homolog 4 (Drosophila) | 0.67 | 0.73 | 2.02 | 1.33 | 2.00E-04 |  |
 | Klf2 | Kruppel-like factor 2 (lung) | 1.28 | 0.82 | 0.78 | 0.57 | 1.00E-04 |  |
 | Tle1 | transducin-like enhancer of split 1, homolog of Drosophila E(spl) | 0.87 | 1.88 | 0.77 | 0.56 | 0.0012 |  |
 | Junb | Jun-B oncogene | 1.41 | 0.51 | 0.65 | 0.53 | < 1.00E-04 | [9] (S) |
 | Cnot4 | CCR4-NOT transcription complex, subunit 4 | 0.71 | 1.39 | 0.66 | 0.46 | 4.00E-04 |  |
 | Fos | FBJ osteosarcoma oncogene | 1.47 | 0.57 | 0.54 | 0.39 | 1.00E-04 | |
 | Mysm1 | myb-like, SWIRM and MPN domains 1 | 1.48 | 2.42 | 0.84 | 0.33 | < 1.00E-04 |  |
Biosynthetic process | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | 0.97 | 0.52 | 1.34 | 2.37 | 4.00E-04 | Â |
 | Rpl17 | ribosomal protein L17 | 1.32 | 1.38 | 0.34 | 0.66 | 4.00E-04 |  |
 | Pbx1 | pre B-cell leukemia transcription factor 1 | 0.46 | 1.51 | 0.79 | 0.54 | < 1.00E-04 |  |
 | 2310043N10Rik (Neat1 (PROVISIONAL)) | RIKEN cDNA 2310043N10 gene (nuclear paraspeckle assembly transcript 1 (non-protein coding) (PROVISIONAL)) | 0.90 | 1.64 | 0.71 | 0.38 | < 1.00E-04 |  |
 | 4933439C20Rik (pisd-ps3 PROVISIONAL) | RIKEN cDNA 4933439C20 gene (phosphatidylserine decarboxylase, pseudogene 3 (PROVISIONAL) | 0.79 | 2.67 | 0.99 | 0.14 | 5.00E-04 |  |
Others | MGI:1929709 | plasma membrane associated protein, S3-12 | 0.87 | 1.54 | 1.98 | 2.73 | < 1.00E-04 | [18] (S) |
 | 1700047I17Rik (fam177a (PREDICTED)) | RIKEN cDNA 1700047I17 gene (family with sequence similarity 177, member A (PREDICTED)) | 1.77 | 0.52 | 1.81 | 2.57 | 1.00E-04 |  |
 | Cd52 | CD52 antigen | 1.16 | 0.91 | 0.88 | 2.54 | < 1.00E-04 | |
 | 4930511A21Rik (ppp2r3c (VALIDATED)) | RIKEN cDNA 4930511A21 gene (protein phosphatase 2, regulatory subunit B'', gamma (VALIDATED)) | 1.36 | 0.64 | 1.33 | 1.83 | 7.00E-04 |  |
 | AU020206 | expressed sequence AU020206 | 1.01 | 0.94 | 0.99 | 1.83 | 3.00E-04 | [18] (S) |
 | A2m | alpha-2-macroglobulin | 0.88 | 0.91 | 1.02 | 1.76 | 1.00E-04 | |
 | Ifi44 | interferon-induced protein 44 | 0.82 | 0.97 | 0.87 | 1.74 | 0.0011 |  |
 | AI467657 (Zbtb16 (PROVISIONAL) | expressed sequence AI467657 (zinc finger and BTB domain containing 16 (PROVISIONAL)) | 0.76 | 1.53 | 2.09 | 1.61 | < 1.00E-04 |  |
 | Mapk4 | mitogen-activated protein kinase 4 | 0.87 | 0.93 | 1.81 | 1.32 | < 1.00E-04 |  |
 | Atxn7l4 | ataxin 7-like 4 | 0.55 | 1.24 | 0.87 | 0.74 | 8.00E-04 |  |
 | Cdca1 | cell division cycle associated 1 | 0.59 | 1.25 | 0.89 | 0.61 | < 1.00E-04 |  |
 | 1700063D05Rik | RIKEN cDNA 1700063D05 gene | 1.01 | 0.90 | 0.95 | 0.60 | < 1.00E-04 |  |
 | 2700081O15Rik | RIKEN cDNA 2700081O15 gene | 0.98 | 1.13 | 0.98 | 0.59 | < 1.00E-04 |  |
 | Btg2 | B-cell translocation gene 2, anti-proliferative | 1.20 | 0.83 | 0.86 | 0.58 | 2.00E-04 | [38] (S) |
 | Lrfn5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.54 | 1.67 | 0.81 | 0.57 | 5.00E-04 | [33] (S) |
 | Gm1075 | gene model 1075, (NCBI) | 1.31 | 0.74 | 0.56 | 0.56 | < 1.00E-04 |  |
 | Prp19 | PRP19/PSO4 homolog (S. cerevisiae) | 0.95 | 1.42 | 1.25 | 0.48 | < 1.00E-04 | [10] (BSE) |
 | R75368 (palm2 (VALIDATED)) | expressed sequence R75368 (paralemmin 2 (VALIDATED)) | 1.06 | 2.49 | 0.62 | 0.47 | 5.00E-04 |  |