Brain sections of boTg110 terminal stage mice (275 dpi) and mock inoculated matched controls. Upper panel: GFAP immunostaining in the medulla oblongata. Note the astrocyte activation in the BSE-inoculated mice at terminal stages (B) in comparison with the control group (A). Middle panel: MT1+2 immunostaining in the cerebellum. Note the increased presence of stellate shaped cells in the BSE-inoculated group (D) at a terminal stage. Lower panel: Lectin staining in the medulla oblongata. Note the proliferation of microglia in BSE-inoculated mice (F).