From: Host cell factors involved in classical swine fever virus entry
Cellular factor/protein | Functions | CSFV partner | References |
---|---|---|---|
CD46 | - Acts as a complement regulator - BVDV receptor | Probably E2 | |
ADAM17 | - Intervenes in the processing of transmembrane proteins | E2 | [65] |
Heparan sulfate | - Prevents degradation of proteins/substances - Acts as an endocytosis receptor - Is involved in the attachment of multiple virus | Erns | |
Laminin receptor | - Cellular receptor - Is involved in adeno-associated virus infection | Erns | [35] |
Integrin ß3 | - Is involved in proliferation and migration of endothelial cells - Acts as receptor/co-receptor for other viruses | ? | |
Annexin II | - Participates in membrane trafficking - Has ion channel activity - Participates in DNA replication - Acts as a virus receptor | E2 | |
MERKT | - Is involved in the phagocytic clearence of apoptotic cells - Potentiates virus infection | E2 |