Figure 2

The biocompatible effect of CATH-1 in vitro and in vivo. Hemolytic activity of CATH-1 was performed using mice red blood cells (A). Cell viability of peritoneal macrophages (B) and PK-15 cells (C) treated with CATH-1 were tested according to WST-1 assay. Mice (n = 10, each group n = 5) were intraperitoneally injected with 10 mg/kg CATH-1 and PBS as a negative control. Body weight was monitored daily for 7 days and variation in body weights (%) are shown (D). Then, H&E staining was performed to observe histopathological changes in lung, liver, and spleen tissues (E) and evaluate the blood chemistries (F) at 7 days.