Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro

Table 3 Anti-ASFV activity of the test compounds and their effects on PAM viability.

Compounds	CC₅₀ (µM)	IC₅₀ (µM)	SI
Genistein	40.69	7.29	5.59
Kaempferol	115.87	9.55	12.13
Quercetin	336.42	19.38	17.40
Naringenin	595.4	46.98	12.67
Formononetin	600.89	97.77	6.14
Resveratrol	62.41	6.01	10.38
Luteolin	79.11	4.48	17.66
Cinnamaldehyde	531.5	150.6	3.5
Ginsenoside Rb1	229.09	120.3	1.90
Sinensetin	400.43	68.50	5.85
Isofraxidin	692.38	540.29	1.28
Mycophenolic acid	539.4	380.63	1.42
11-Keto-β-boswellic acid	356.7	241.77	1.48
Paeonol	965.87	720.12	1.34
Matrine	106.67	80.63	1.32
Licochalcone A	102.9	10.41	9.88
Dihydromyricetin	532.1	20.06	26.53

CC₅₀, 50% cytotoxic concentration; IC₅₀, half maximal inhibitory concentration; SI, selectivity index

ISSN: 1297-9716