Group | Animal | Serum | BALF |
---|
Pre-challenge | 14Â dpi/16Â dpc | 14Â dpi/16Â dpc |
---|
AERO low | A | 16 | 32 | 16 |
B | 4 | 64 | 32 |
C | 8 | 64 | 32 |
D | 8 | 32 | 8 |
IN low | E | 16 | 64 | 16 |
F | 16 | 16 | 16 |
G | 8 | 128 | 16 |
H | 16 | 32 | 16 |
AERO high | I | 16 | 256 | 64 |
J | 8 | 256 | 64 |
K | 16 | 256 | 64 |
IN high | L | 8 | 32 | 16 |
M | 8 | 64 | 16 |
N | 16 | 128 | 16 |
IN contact | O | 16 | 256 | 32 |
P | 16 | 64 | 16 |
Q | 16 | 64 | 16 |
AERO contact | R | 8 | 128 | 16 |
S | 16 | 128 | 32 |
T | 8 | 256 | 32 |
- HA titres were determined in serum and BAL fluid at day of sacrifice (14 or 16 dpc) using 4 HAI units of A/Sw/Eng/1353/09 virus. Results shown are the mean of all individuals in each of the groups ± standard deviation. Serum from pigs immunized with commercial A(H1N1)pdm09 vaccine Pandemrix (GSK) and challenged with A/England/195/09 (pdmH1N1) virus as previously described [11] was used as a positive control and gave a titer of 2048.