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Figure 9 | Veterinary Research

Figure 9

From: Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens

Figure 9

Hypothetical model of IBV B1648 and M41 replication kinetics in respiratory mucosa, blood and internal organs of chickens. Stars represent infectious virus. Star number and infectivity are directly proportional to each other. After natural entry of virus through nostrils, both nephropathogenic IBV B1648 and M41 replicate in the tracheal mucosa. B1648 uses a higher number of infected KUL01+ cells as carriers to penetrate deeper in the layers of the respiratory mucosa in contrast to M41. B1648 productively infects KUL01+ blood monocytic cells while M41 infection is abortive. Only B1648 disseminates via a cell-associated viremia in mononuclear leukocytes and cell free virus in plasma to reach lungs, liver, spleen and kidneys. B1648 productive infection is present in kidneys and to a less degree in lungs, liver and spleen.

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Veterinary Research

ISSN: 1297-9716