Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Table 2 Differential expression of genes involved in key biological functions between HPAIV infected chicken and duck cells (detected by microarray)

Gene symbol	Gene name	Entrez Gene ID	Chicken cells				Duck cells
Gene symbol			H5N1-tyEng91		H5N1-tyTR05		H5N1-tyEng91		H5N1-tyTR05
			Fold change	Regulation	Fold change	Regulation	Fold change	Regulation	Fold change	Regulation
Signal transduction
PRKAR2A	Protein kinase, cAMP-dependent, regulatory, type II, alpha	416062	2.27	up	4.59	down	3.96	down	5.86	down
IPO7	Importin 7	423046	-	unchanged	2.21	down	4.83	up	2.99	down
GTPase inhibitor activity
GPS1	G protein pathway suppressor 1	417382	2.86	down	3.01	down	2.21	up	3.2	up
Lipid metabolism, production of ROS
ACOX1	Acyl-Coenzyme A oxidase 1, palmitoyl	417366	4.33	down	2.88	down	-	unchanged	3.24	up
Enzymes
B4GALNT3	Beta-1,4-N-acetyl-galactosaminyl transferase 3	418150	2.07	down	1.33	up	2.58	up	2.08	up
DNPEP	Aspartyl aminopeptidase	424200	2.38	up	1.3	up	-	unchanged	1.44	down
Catalytic activity (vit B6 metabolism)
PSAT1	Phosphoserine aminotransferase 1	427263	4.38	down	3.9	down	11.44	up	11.69	up
Transcription factor
RREB1	Ras responsive element binding protein 1	395920	3.41	down	2.26	down	2.73	up	7.31	up
Isoleucyl-tRNA aminoacylation
IARS2	Isoleucyl-tRNA synthetase 2, mitochondrial	421346	17.58	down	22.92	down	14.52	up	38.82	up
Peptidolysis, IL-4 biosynthesis
MMP28	Matrix metallopeptidase 28	417523	2.66	down	1.93	down	3.31	up	10.38	up

ISSN: 1297-9716