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Table 5 Genes most significantly differentially expressed by bMEC stimulated by SaS for 3 and 6 h compared to unstimulated cells, ordered by functional classes

From: Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

Gene symbol

Gene description

Fold change

3 h

6 h

Transcription and activation pathways

  

  FOS

Proto-oncogene protein c-fos

2.09

2.21

  NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

2.15

2.07

  DUSP1

dual specificity phosphatase 1

1.91

1.71

  ETS2

erythroblastosis virus E26 oncogene homolog 2 (avian)

 

1.72

  CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

1.65

1.59

  SQSTM1

sequestosome 1

 

1.58

  BIRC3

Baculoviral IAP repeat-containing 3

1.56

 

  IKBKAP

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

 

1.49

  JUN

Jun oncogene

1.57

1.47

  NFKB2

nuclear factor of κ light polypeptide gene enhancer in B-cells 2

-2.05

 

  FUS

RNA-binding protein FUS

 

-1.82

  SFRS3

Splicing factor, arginine/serine-rich 3

 

-1.71

  SFPQ

splicing factor proline/glutamine-rich

 

-1.59

  RABL3

RAB, member of RAS oncogene family-like 3

 

-1.57

  U2AF1

Splicing factor U2AF

 

-1.54

  CSTF2

cleavage stimulation factor, 3′pre-RNA, subunit 2

 

-1.53

  RDBP

RNA-binding protein RD, Negative elongation factor E

 

-1.47

  DKC1

dyskeratosis congenita 1, dyskerin

 

-1.47

  CRSP9

Cofactor required for Sp1 transcriptional activation subunit 9

-1.45

 

Cytokines and chemokines

  

  CXCL8

Chemokine (C-X-C motif) ligand 8, Interleukin-8

6.20

4.52

  CCL20

chemokine (C-C motif) ligand 20

4.94

4.27

  CXCL1

Chemokine (C-X-C motif) ligand 1

3.51

 

  CXCL3

Chemokine (C-X-C motif) ligand 3

2.48

 

  CCL2

chemokine (C-C motif) ligand 2

2.22

2.71

  CXCL5

chemokine (C-X-C motif) ligand 5

 

2.57

  CXCL2

chemokine (C-X-C motif) ligand 2

 

2.47

  IL6

Interleukin 6

1.71

 

  VEGFB

Vascular endothelial growth factor B Precursor

 

1.47

Immune defense response

  

  PLAUR

urokinase plasminogen activator surface receptor

1.70

2.46

  LBP

lipopolysaccharide binding protein

 

2.26

  NOS2A

Nitric oxide synthase 2A (inducible)

 

2.05

  CD83

Cell surface protein HB15

1.89

1.73

  CFB

complement factor B

 

1.70

  SQSTM1

sequestosome 1

 

1.58

  TLR4

toll-like receptor 4

 

1.50

  ILRAP

interleukin 1 receptor accessory protein

 

1.44

  CD96

Cell surface antigen CD96

 

1.31

  C3

Complement factor 3

 

-1.35

  MMP9

Matrix metallopeptidase 9

-1.33

 

Stress response

  

  SGK1

serum/glucocorticoid regulated kinase 1

1.73

1.75

Cell growth and cycle, apoptosis

  

  IER3

immediate early response 3

1.99

1.58

  RASSF1

Ras association domain-containing protein 1

 

1.52

  CDKN2B

cyclin-dependent kinase inhibitor 2B

 

-1.85

  CDC20

cell division cycle 20 homolog (S. cerevisiae)

 

-1.60

  CCNA2

cyclin A2

 

-1.37

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Veterinary Research

ISSN: 1297-9716