Figure 8
Representative images of predominant PrPScdeposition types associated with each strain in C57BL/6 and VM mouse lines. (a and b) Aggregates of varying size associated with ME7 in C57BL/6 and VM lines, respectively; (c) fibrillar plaques associated with 87A in C57BL/6 mice; (d) large dense aggregates observed with 87V in VM mice; (e and f) “mottled” deposition in the thalamic nuclei associated with 221C and VLA-V1 in C57BL/6 and VM mice, respectively. Scale bars represent 100 μm.