From: Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review
Organ | Lesions |
---|---|
Liver | Enlarged with marked lobular pattern, yellow-grey colour, brittle, circumscribed infiltration with granulocytes, degenerative alterations of hepatocytes compatible with apoptosis (extensive vacuolization, severe alterations in the mitochondrial structure, karyopyknosis and karyolysis) activation of Kupffer cells, leukopenia |
Trachea | Hyperaemia of mucous membrane, petechial or diffuse haemorrhages, may be filled with bloody foam |
Lung | Hyperaemia, pulmonary oedema, intra-alveolar and perivascular haemorrhages, sometimes slight catarrhal bronchiolitis, proliferation of lymphocytes |
Kidneys | Enlargement with spotted dark red coloration, hyperaemia, haemorrhages within glomerular loops and renal medulla, hyaline thrombi, dilated tubuli, lymphocytic infiltration, degeneration of tubular epithelium |
Spleen | Enlargement (splenomegaly), spotted dark red colorations, hyperaemia, occasionally karyorrhexis within follicles, hemosiderosis, leukopenia |
Digestive tract | Contents usually normal, occasional enteritis, subserous haemorrhages |
Chest and abdominal cavity | Small amounts of serous, occasionally bloody exudate, sometimes subserous haemorrhages |
Muscles | Anaemia in the area of the thighs, petechiae in the heart muscle, focal necrosis in myocardium, degenerative alterations, hemosiderosis |
Central Nervous System | Congestion of cortical vessels, dilated vessels in the area of the pia mater of the cortex and cerebellum, hyperaemia, small haemorrhages in the cortex, occasionally non-purulent encephalomyelitis with lymphocytic infiltration |