From: The current status and future directions of myxoma virus, a master in immune evasion
Gene product | Potential clinical use | References |
---|---|---|
Serp-1 | Secreted serpin that effectively inhibits vascular inflammatory responses and has been tested in human clinical trials to treat acute coronary syndrome. | |
Serp-2 | Viral anti-apoptotic serpin effective in animal models but not yet tested in humans. | [19] |
M-T1 | Chemokine inhibitor that reduces the allograft rejection and stabilizes plaque formation during artherosclerosis. | |
M-T7 | Chemokine inhibitor that attenuates systemic inflammatory responses and inhibits leukocyte infiltration, thus preventing transplant rejection. | |
M-T2 | TNF/TNFR inhibitor but not yet tested as a potential therapeutic. |